| Cat. No. |
Product Name |
Information |
| PC-23555 |
R162
GLUD1 inhibitor
|
R162 is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 28.6 uM, inhibits cancer cell proliferation and tumor growth. |
| PC-23530 |
LDR102
ROR1 inhibitor
|
LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity. |
| PC-23529 |
ARI-1
ROR1 inhibitor
|
ARI-1 is a specific inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1), directly targets the frizzled domain with high binding affinity, inhibits EGFR-TKIs-resisted NSCLC with high ROR1 expression. |
| PC-23519 |
Necrocide 1
Necrosis inducer, TRPM4 activator
|
Necrocide 1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively. |
| PC-23517 |
ATX968
DHX9 inhibitor
|
ATX968 is a potent and selective inhibitor of DHX9 helicase activity with DHX9 unwinding IC50 of 8 nM, SPR Kd value of 1.3 nM. |
| PC-23494 |
Ibetazol
Importin β inhibitor
|
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1. |
| PC-23451 |
PF-07328948
BDK inhibitor
|
PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay. |
| PC-23404 |
NAC1 inhibitor NIC3
NAC1 inhibitor
|
NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation. |
| PC-23325 |
Stomidazolone
Stomatal differentiation inhibitor
|
Stomidazolone is a doubly-sulfonylated imidazolone that inhibits stomatal differentiation, tightly binds to C-terminal ACT-Like (ACTL) domain of MUTE (Kd=8.9 uM) and perturbs the SCRM-MUTE heterodimerization. |
| PC-23304 |
PGMI-004A
PGAM1 inhibitor
|
PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM. |
| PC-23289 |
C071-0684
CHD1L inhibitor
|
C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells. |
| PC-23286 |
HKi2
HEG1-KRIT1 inhibitor
|
HKi2 (HEG1-KRIT1 inhibitor 2) is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=3.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation. |
