| Cat. No. |
Product Name |
Information |
| PC-26013 |
GPR83 agonist CPD1
GPR83 agonist
|
GPR83 agonist CPD1 is a potent, selective small molecule GPR83 agonist with binding IC50 of 10 nM, induces dose-dependent increases in intracellular Ca+2 release in CHO cells expressing mouse GPR83 with EC50 of 74 nM. |
| PC-26000 |
Iodomethylcholine
CutC/D inhibitor
|
Iodomethylcholine (IMC) is a highly potent non-lethal, irreversible and non-competitive TMA-generating enzyme CutC/D inhibitor with IC50 of 1.2 nM against Proteus mirabilis CutC/D, reduces TMAO levels in vivo. |
| PC-25999 |
Fluoromethylcholine
TMA Lyase inhibitor
|
Fluoromethylcholine (FMC) is a highly potent TMA Lyase inhibitor in Escherichia coli (IC50 = 900 pM against Proteus mirabilis CutC/D) and in a polymicrobial human fecal culture (IC50 = 7.9 nM). |
| PC-25996 |
ADAR1i-124
ADAR1 inhibitor
|
ADAR1i-124 is a selective inhibitor of the ADAR1 A-to-I RNA editing activity with in vitro editing IC50 values of 10-30 uM, inhibits the catalytic activities of both ADAR1p150 and ADAR1p110. |
| PC-25994 |
LP-856866
ACSL5 inhibitor
|
LP-856866 (ACSL5i) is a potent, selective inhibitor of Acyl-CoA Synthetase 5 (ACSL5) with IC50 of 4 nM and 8 nM for huamn and mouse ACSL5 in acyl-CoA synthetase (ACS) assays, highly selective against ACSL3. |
| PC-25980 |
AVIL inhibitor Compound A
Advillin inhibitor
|
AVIL inhibitor Compound A (PLH1215) is a specific small molecule actin-binding protein advillin (AVIL)-interacting compound with MST Kd of 6 uM, also blocks AVIL binding to its substrate actin. |
| PC-25859 |
Lysosome inhibitor LLAD
SLC38A9 inhibitor
|
LLAD is a long-term lysosome-targeting anticancer drug, inhibits SLC38A9 in lysosomes and alkalinizes lysosomes, induces apoptosis through long-term lysosomal damage in vivo and in vitro. |
| PC-25818 |
DS89092425
PUF60-UHM inhibitor
|
DS89092425 is a small molecule RNA splicing factor PUF60-UHM inhibitor with ITC KD of 83 uM. |
| PC-25817 |
Claudin 5 binder CL5B
CLDN5 binder
|
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery. |
| PC-25807 |
Ciliogenesis inhibitor Nao-3
Ciliogenesis inhibitor
|
Ciliogenesis inhibitor Nao-3 (Naonedin-3) is specific small-molecule inhibitor of ciliogenesis, represses primary ciliogenesis and induces the death of chemoresistant ciliated stem-like cells. |
| PC-25797 |
JPC0661
ΔFOSB inhibitor
|
JPC0661 is a specific small molecule direct inhibitor of AP1 transcription factor ΔdeltaFOSB (ΔFOSB), inhibits FOSB/JUND and ΔFOSB DNA-binding biochemically with IC50 of 9 uM and 52 uM respectively. |
| PC-25682 |
Ferovicin
FERONIA receptor inhibitor
|
Ferovicin is a specific small molecule inhibitor FERONIA (FER) receptor kinase with IC50 of 70 nM, selectively binds to the ATP-binding pocket of the kinase domain of FER and inhibits its kinase activity. |
