| Cat. No. |
Product Name |
Information |
| PC-28039 |
HUHS199
ALKBH3 inhibitor
|
HUHS199 is a potent small molecule inhibitor of prostate cancer antigen-1 (PCA-1, ALKBH3), potently inhibits the RNA demethylase activity of ALKBH3 with IC50 of 0.17 uM in ELISA assays. |
| PC-27692 |
CRT0044876
APE1 inhibitor
|
CRT0044876 is a potent, specific apurinic/apyrimidinic endonuclease 1 (APE1, also termed HAP1 and Ref-1) inhibitor with IC50 of 3.06 uM, inhibits base excision repair. |
| PC-27690 |
MAD2L2 inhibitor C#3
MAD2L2 inhibitor
|
MAD2L2 inhibitor C#3 (ZINC25496030) is a small-molecule inhibitor of DNA polymerase Pol ζ (zeta) regulatory subunit MAD2L2 (Rev7), disrupts the MAD2L2-Rev1 interaction, potentially causes mutagenic translesion synthesis (TLS) inhibition, sensitizes lung cancer cell lines to cisplatin. |
| PC-27257 |
MWAC-1657
TREX1 inhibitor
|
MWAC-1657 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 154 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2. |
| PC-27256 |
MWAC-1655
TREX1 inhibitor
|
MWAC-1655 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 64.2 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2. |
| PC-27097 |
SU0617
SMUG1 inhibitor
|
SU0617 is a specific small molecule inhibitor of DNA repair enzyme SMUG1 with IC50 of 1.5 uM. |
| PC-26961 |
NSC37215
TREX1 inhibitor
|
NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively. |
| PC-26959 |
TREX1-IN-3
TREX1 inhibitor
|
TREX1-IN-3 (Compound 95) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM, and has EC50 for HCT116 cells of < 1 μM. |
| PC-26604 |
NP1867
PMS2 inhibitor
|
NP1867 (NP-1867) is a potent, first-in-class small molecule DNA mismatch repair (MMR) pathway modulator targeting PMS2 (PMS1 Homolog 2) with SPR KD of 65 nM for PMS2-N-terminal ATPase domain, IC50 of 22 nM in NanoBRET assays, blocks PMS2-NTD ATP binding site and inhibits DNA MMR. |
| PC-25978 |
Thymine DNA glycosylase inhibitor C-271
TDG inhibitor
|
C-271 is a first-in-class, specific small-molecule inhibitor of Thymine DNA glycosylase (TDG), inhibits TDG's glycosylase activity with similar efficacy across different substrates with IC50 of 0.16-0.25 uM, covalently targets TDG at C276. |
| PC-25188 |
TREX1-IN-1
TREX1 inhibitor
|
TREX1-IN-1 is a potent, effective inhibitor of cytosolic DNA exonuclease TREX1 (three-prime repair exonuclease 1) with IC50 of <0.1 uM for human TREX1. |
| PC-24665 |
GSK4418959
WRN inhibitor
|
GSK4418959 (IDE275) is a potent, non-covalent, reversible Werner helicase (WRN) inhibitor, binds to WRN in an allosteric pocket and inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. |
