| Cat. No. |
Product Name |
Information |
| PC-24628 |
BMA097
STAT3 inhibitor
|
BMA097 is a small molecule STAT3 inhibitor with IC50 of 1.8 uM in STAT3-dependent luciferase assays, binds directly to the SH2 domain of STAT3 and specifically inhibits STAT3 Tyr705 phosphorylation and activation. |
| PC-24625 |
LLY17
STAT3 inhibitor
|
LLY17 (Compound 9) is an orally available, potent, and selective STAT3 inhibitor, directly and selectively inhibits the pY705 site of STAT3 with Ki of 400 nM. |
| PC-24624 |
SMY002
STAT3 inhibitor
|
SMY002 is a potent novel small molecule STAT3 inhibitor, directly interacts and binds to STAT3 with SPR IC50 of 2 uM, inhibits the transcriptional activity of STAT3. |
| PC-24235 |
Pomstafori-1
STAT4 inhibitor
|
Pomstafori-1 is the cell-permeable prodrug of Stafori-1, inhibits STAT4 Tyr693 phosphorylation in NK-92 cell with IC50 of 3.3 uM, selectively inhibits STAT4 activation and IFN-γ induction in cultured human cells. |
| PC-23511 |
HJC0416 hydrochloride
STAT3 inhibitor
|
HJC0416 hydrochloride is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM. |
| PC-22565 |
Fludarabine
STAT1 inhibitor, NAT10 inhibitor
|
Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. |
| PC-22095 |
YY002
STAT3 inhibitor
|
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation. |
| PC-21893 |
Stattic
STAT3 inhibitor
|
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro. |
| PC-21874 |
WZ-2-033
STAT3 inhibitor
|
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling. |
| PC-20934 |
WB737
STAT3 inhibitor
|
WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM. |
| PC-20634 |
IST5-002
Stat5 inhibitor
|
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells. |
| PC-20465 |
S3I-201
STAT3 inhibitor
|
S3I-201 (NSC74859, S31-201) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM. |
