| Cat. No. |
Product Name |
Information |
| PC-28052 |
QX03-46
CTGF inhibitor
|
QX03-46 is a first-in-class small-molecule inhibitor targeting connective tissue growth factor (CTGF), significantly disrupts the CTGF/TGF-β1 signaling axis and suppresses cancer-associated fibroblast (CAF) functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion in PDAC. |
| PC-24853 |
RK783
ACVR1 inhibitor
|
RK783 is a potent, selective inhibitor inhibitor of BMP type 1 receptor kinase (ACVR1), inhibits CVR1-Q207D, ACVR1-R206H, wild-type ACVR1, and other BMP type 1 receptor kinases with IC50 of 10-120 nM. |
| PC-24588 |
GFH018
TGF-βRI inhibitor
|
GFH018 is a small molecule inhibitor of transforming growth factor-β receptor I (TGF-βRI, ALK5) inhibitor with IC50 of 40 nM, >60-fold selective over p38α MAPK. |
| PC-24274 |
HM-279
ALK5 inhibitor
|
HM-279 is a potent, selective, orally bioavailable inhibitor of ALK5 (TGFβR1) with IC50 of 4.7 nM, strongly inhibits the phosphorylation of Smad3 in A549 cells (IC50=21.6 nM). |
| PC-24165 |
Ontunisertib
ALK5 inhibitor
|
Ontunisertib (AGMB-129, AGMB129) is a potent, selective, oral, gastrointestinal-restricted TGF-beta type I receptor (TGFβRI)/ALK5 kinase inhibitor. |
| PC-22015 |
M4K2009
ALK2 inhibitor
|
M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM). |
| PC-21414 |
TP-0184
ALK2 inhibitor
|
Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2). |
| PC-21393 |
LDN-212854
ALK2 inhibitor
|
LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM). |
| PC-21392 |
NUCC-555
Activin inhibitor
|
NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM. |
| PC-49711 |
CDD-1115
BMPR2 inhibitor
|
CDD-1115 (CDD1115) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.8 nM and Kiapp of 6.2 nM. |
| PC-49710 |
CDD-1653
BMPR2 inhibitor
|
CDD-1653 (CDD1653) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 2.8 nM, >360-fold over ALK1, and is inactive versus all other type 1 and type 2 TGFβ family kinases. |
| PC-49709 |
CDD-1281
BMPR2 inhibitor
|
CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM. |
