QX03-46 | CTGF inhibitor | Probechem Biochemicals

Chemical Structure : QX03-46

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QX03-46 (QX 03-46)

货号: PC-28052Not For Human Use, Lab Use Only.

QX03-46 is a first-in-class small-molecule inhibitor targeting connective tissue growth factor (CTGF), significantly disrupts the CTGF/TGF-β1 signaling axis and suppresses cancer-associated fibroblast (CAF) functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion in PDAC.

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生物&药学活性

QX03-46 is a first-in-class small-molecule inhibitor targeting connective tissue growth factor (CTGF), significantly disrupts the CTGF/TGF-β1 signaling axis and suppresses cancer-associated fibroblast (CAF) functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion in PDAC.

物理化学性质&存储条件

分子量	424.49
分子式	C24H28N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(3,4-diethoxy-5-methoxyphenyl)vinyl)-6-methoxy-2-methyl-1H-indole-7-carboxamide

参考文献

1. Shen Y, et al. Proc Natl Acad Sci U S A. 2026 Sep 8;123(36):e2535905123.

2. Patent CN118324684 A 2024-07-12.

QX03-46 (QX 03-46)

生物&药学活性

物理化学性质&存储条件

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QX03-46 (QX 03-46)

生物&药学活性

物理化学性质&存储条件

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