| Cat. No. |
Product Name |
Information |
| PC-28376 |
ST171
5-HT1A agonist
|
ST171 (ST-171) is a potent, functionally selective agonist of 5-HT1A receptor (5-HT1AR) with Ki of 0.41 nM, has 680-fold subtype selectivity over 5-HT2AR and 8000-fold selectivity over 5-HT6R, selectively activates 5-HT1AR-mediated Gi/o signaling. |
| PC-28264 |
IHCH-2330
5-HT2A agonist
|
IHCH-2330 is a potent, selective 5-HT2AR agonist with Ki of 7.24 nM and 45.71 nM for 5-HT2AR and 5-HT2BR respectively, simultaneously antagonizing 5-HT2BR. |
| PC-28049 |
25CN-NBOH hydrochloride
5-HT2A agonist
|
25CN-NBOH hydrochloride is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin). |
| PC-27530 |
IHCH-8110
5-HT2AR agonist
|
IHCH-8110 is a potent, selective, non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist with Ki of 47.86 nM, inhibits CRC progression by activating 5-HT2AR on enteric glial cells. |
| PC-27525 |
Mosapride
5-HT4 agonist
|
Mosapride (AS-4370) is a gastroprokinetic agent that acts as a selective 5-HT4 agonist, has concentration-dependent inhibitory effect on Kv4.3. |
| PC-27155 |
DSP-2342
5-HT2A/5-HT7 antagonist
|
DSP-2342 is potent, selective 5-hydroxytryptamine 2A/7 (5-HT2A/5-HT7) receptor antagonist with binding Ki of 1.15 nM and 2.92 nM for human 5-HT2A and 5-HT7 respectively, IC50 of 24.8 nM and 4.4 nM. |
| PC-27110 |
RS-127445
5-HT2B antagonist
|
RS-127445 (MT-500, RS127445) is a potent, selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with pKi of 9.5, 1,000 fold selectivity over numerous other receptor and ion channel binding sites. |
| PC-26559 |
JZ-1201
SERT/NET inhibitor, 5-HT1A agonist
|
JZ-1201 is a selective serotonin (5-HT)/norepinephrine (NE) reuptake inhibitor and partial agonist of the 5-HT1A receptor, selectively binds to the SERT, NET, and 5-HT1A receptor with Ki values of 1.62 nM, 0.87 nM, and 0.22 nM, exerts antidepressant-like effects. |
| PC-26337 |
Lumocaserin
5-HT2C agonist
|
Lumocaserin is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
| PC-25986 |
DOI-NBOMe
5-HT2A agonist
|
DOI-NBOMe is a potent, selective and Gq-biased agonist of 5-HT2A receptor (5-HT2AR) with pEC50 of 8.01. |
| PC-25733 |
TMU4142
5-HT1A agonist
|
TMU4142 is a potent, GoA pathway-selective 5-HT1A receptor (5-HT1AR) agonist with pEC50 of 8.80 (EC50=1.59 nM), Emax=92.78%. |
| PC-25028 |
Remlifanserin
5-HT2A inverse agonist
|
Remlifanserin (ACP-204, ACP204) is a potent, selective 5-HT2A serotonin receptor inverse agonist with Ki of 0.14 nM, acts as an antagonist/inverse agonist and has potencies of 0.3-0.5 nM. |
