TMU4142 | 5-HT1A agonist | Probechem Biochemicals

Chemical Structure : TMU4142

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TMU4142 (TMU-4142)

货号: PC-25733Not For Human Use, Lab Use Only.

TMU4142 is a potent, GoA pathway-selective 5-HT1A receptor (5-HT1AR) agonist with pEC50 of 8.80 (EC50=1.59 nM), Emax=92.78%.

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生物&药学活性

TMU4142 is a potent, GoA pathway-selective 5-HT1A receptor (5-HT1AR) agonist with pEC50 of 8.80 (EC50=1.59 nM), Emax=92.78%.
TMU4142 displays nearly full agonist activity at the 5-HT1AR GoA pathway, whereas its Gi3 activity is significantly lower than that of 5-HT.
TMU4142 strongly activates the GoA protein over other tested Gi/o family proteins.
TMU4142 shows no discernible activity at 5-HT1AR β-arrestin-2 pathway, and weak or no activity at other serotonin and dopamine receptors.
TMU4142 (1.5 mg/kg) elicits rapid antidepressant-like activity without triggering significant DRN autoreceptor activation in mouse model of depression.

物理化学性质&存储条件

分子量	413.52
分子式	C23H31N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-(3-((3-((1H-indol-4-yl)oxy)-2-hydroxypropyl)amino)propyl)-8-azaspiro[4.5]decane-7,9-dione

参考文献

1. Wang C, et al. Cell. 2025 Nov 12:S0092-8674(25)01194-8.

TMU4142 (TMU-4142)

生物&药学活性

物理化学性质&存储条件

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TMU4142 (TMU-4142)

生物&药学活性

物理化学性质&存储条件

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