| Cat. No. |
Product Name |
Information |
| PC-27585 |
Inz-5
Fungal complex III inhibitor
|
Inz-5 is a fungal-specific indazole derivative inhibitor of Candida albicans (C. albicans) complex III (CIII) with IC50 of 24 nM in UQH2:cyt c oxidoreductase assays. |
| PC-27214 |
SYP-14288
Fungicide
|
SYP-14288 is a novel fungicide acts as an uncoupler of oxidative phosphorylation against Phytophthora capsici, inhibits ATP synthesis of the pathogen. |
| PC-25620 |
Isoxazole 1
CnAcs1 inhibitor
|
Isoxazole 1 is a potent, specific inhibitor of C. neoformans acetyl-CoA synthetase (CnAcs1) with IC50 of 8.6 uM, shows antifungal activity against WT C. neoformans strain H99 with MIC of 2 ug/mL. |
| PC-24646 |
Tps1 inhibitor 4456dh
Fungal Tps1 inhibitor
|
Tps1 inhibitor 4456dh is a small molecule inhibitor of the fungal first enzyme in the trehalose biosynthesis pathway, trehalose-6-phosphate synthase (Tps1), demonstrates broad-spectrum inhibitory effects against multiple pathogenic fungal species, including Candida and Cryptococcus. |
| PC-23892 |
ISFP10
AfPGM inhibitor
|
ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme. |
| PC-23298 |
Manogepix
Gwt1 inhibitor
|
Manogepix (APX001A, E1210) is a potent antifungal agent targeting the fungal glycosylphosphatidylinositol acyltransferase Gwt1, demonstrates potent in vitro activity against clinical isolates of both Candida (Candida spp, MIC50/90=0.008/0.12 mg/L) and Aspergillus species. |
| PC-22712 |
MBX-7591
Antifungal agent
|
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles. |
| PC-21852 |
NP-BTA
C. albicans Gln4 inhibitor
|
NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth. |
| PC-21530 |
Phenamacril
Myosin 5 inhibitor
|
Phenamacril (Fungicide JS399-19) is a specific inhibitor of myosin5 protein (Myo5), inhibits ergosterol biosynthesis pathway and exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates. |
| PC-20789 |
Erg6 inhibitor H55
Fungal Erg6 inhibitor
|
Erg6 inhibitor H55 is an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase (Erg6), potently inhibits C. albicans hyphal formation in multiple cultural conditions. |
| PC-49414 |
MMV688766
Antifungal
|
MMV688766 (MMV 688766) is a small molecule displaying broad-spectrum fungicidal activity through perturbation of lipid homeostasis, inhibits the growth of four geographically distinct C. auris clades with MIC80 of 12.5-50 uM. |
| PC-38699 |
YU385599
Fungal PanK inhibitor
|
YU385599 is a potent small molecule inhibitor of fungal pantothenate kinase (PanK) with Ki of 106 nM (A. fumigatus AfPanK), also inhibits S. cerevisiae Cab1 enzyme with Ki of 170 nM, inhibits the growth of several Candida species. |
