| Cat. No. |
Product Name |
Information |
| PC-24377 |
WSD0628
ATM inhibitor
|
WSD0628 (WSD-0628) is a potent, selective, orally bioavailable and CNS penetrant ATM inhibitor, potently inhibits ATM-mediated phosphorylation of the DNA damage response protein KAP1 in MCF-7 cells with IC50 of 0.42 nM. |
| PC-22828 |
AD1058
ATR inhibitor
|
AD1058 is a highly potent, selective, brain-penetrant ATR inhibitor with IC50 of 1.6 nM. |
| PC-22113 |
XRD-0394
ATM/DNA-PK inhibitor
|
XRD-0394 (XRD0394) is a potent and specific dual inhibitor of DNA damage-response kinases ATM and DNA-PK with IC50 of 0.39 and 0.89 nM respectively. |
| PC-21873 |
ART0380
ATR inhibitor
|
Alnodesertib (ART0380, ART-0380) is a potent, selective and ATP-competitive ATR kinase inhibitor, inhibits ATR-ATRIP complex enzyme activity with IC50 of 51.7 nM, and phospho-Chk1 IC50 of 22 nM in cell western assay. |
| PC-21858 |
Tuvusertib
ATR inhibitor
|
Tuvusertib (M1774) is a potent, selective, orally bioavailable ATR protein kinase inhibitor, shows anticancer activity against cance cell with expression the ATR inhibition sensitizing mixed lineage leukemia fusion protein. |
| PC-21522 |
CGK733
ATM/ATR inhibitor
|
CGK733 is a specific small molecule inhibitor of ATM and ATR kinases, induces cell death in prematurely senescent breast cancer cells. |
| PC-73375 |
M3541
ATM inhibitor
|
M3541 (M 3541) is a novel potent, selective and ATP-competitive ATM kinase inhibitor with IC50 of 0.25 nM (ATP, 10 uM). |
| PC-72900 |
M4076
ATM inhibitor
|
Lartesertib (M4076) is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM. |
| PC-72744 |
SKLB-197
ATR inhibitor
|
SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM. |
| PC-72315 |
RP-3500
ATR inhibitor
|
RP-3500 (RP3500, Camonsertib) is a novel potent, selective, orally bioavailable ATR inhibitor with IC50 of 1.0 and 0.33 nM in biochemical and cell-based assays, respectively. |
| PC-72164 |
Berzosertib
ATR inhibitor
|
Berzosertib (M6620, VX-970, VE-822) is a highly potent, selective ATR inhibitor with Ki of 0.17 nM, pH2AX IC50 of 19 nM. |
| PC-72163 |
M4344
ATR inhibitor
|
M4344 (VX-803, Gartisertib) is a highly potent, selective ATR inhibitor with Ki<0.15 nM. |
