| Cat. No. |
Product Name |
Information |
| PC-24401 |
GH501
Skp1-Skp2 inhibitor
|
GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF). |
| PC-23528 |
iBFAR2
BFAR inhibitor
|
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice. |
| PC-22133 |
LS-102
Synoviolin inhibitor
|
LS-102 is a selective small molecule inhibitor of E3 ubiquitin ligase Synoviolin (SYVN1), inhibits the autoubiquitination of synoviolin with IC50 of 35 uM. |
| PC-21791 |
MN714
SOCS2 inhibitor
|
MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2). |
| PC-21790 |
MN551
SOCS2 inhibitor
|
MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate. |
| PC-21767 |
AAA-237
Skp2 inhibitor
|
AAA-237 (SCFSkp2-IN-2) is a small molecule Skp2 E3 ligase inhibitor, binds to Skp2 protein (KD=28.77 uM) and inhibits the degradation of Skp2 substrates, inhibits the proliferation of the NSCLC cells. |
| PC-21766 |
Smurf1 inhibitor A01
Smurf1 inhibitor
|
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level. |
| PC-21555 |
C7683
Cbl-b inhibitor
|
C7683 is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC5 of <1 nM, an analogue of Nx-1607. |
| PC-21554 |
NX-1607
Cbl-b inhibitor
|
Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM. |
| PC-21396 |
SMIP004
Skp2 inhibitor
|
SMIP004 is a small molecule inducer of cancer-cell selective apoptosis and S-phase kinase-associated protein 2 (Skp2) inhibitor, shows anti-cancer and antidepressant-like activities. |
| PC-21374 |
Nimbolide
RNF114 inhibitor
|
Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping. |
| PC-21056 |
Skp2-2
Skp2-Cks1 inhibitor
|
Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells. |
