| Cat. No. |
Product Name |
Information |
| PC-20550 |
T0467
PINK1-Parkin activator
|
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1. |
| PC-20317 |
BC1464
FBXO7 inhibitor
|
BC1464 (BC 1464) is a small molecule inhibitor of ubiquitin E3 ligase receptor component FBXO7, efficiently decreases the interaction between FBXO7 and PINK1, increases cellular PINK1 concentrations and activities. |
| PC-20292 |
OICR-8268
DCAF1 ligand
|
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP). |
| PC-20113 |
PELI1-EGFR inhibitor S62
PELI1/EGFR inhibitor
|
PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis. |
| PC-49510 |
NAB2
Nedd4 inhibitor
|
NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM. |
| PC-49453 |
Thiolutin
HOIP inhibitor
|
Thiolutin (Acetopyrrothin) is a small molecule inhibitor of the catalytic activity of E3 ubiquitin ligase RING finger protein 31 (RNF31, also known as HOIP), a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC). |
| PC-49196 |
BC18630 free base
DCAF7 inhibitor
|
BC18630 free base (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays. |
| PC-49194 |
BC18813
DCAF7 inhibitor
|
BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays. |
| PC-49193 |
BC18630
DCAF7 inhibitor
|
BC18630 (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays. |
| PC-49083 |
Z0933M
Skp1 inhibitor
|
Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays. |
| PC-38778 |
WSB1 inhibitor 4
WSB1 inhibitor 4
|
WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells. |
| PC-38449 |
BC-1258
FBXO3 inhibitor, FBXL2 activator
|
BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo. |
