| Cat. No. |
Product Name |
Information |
| PC-27513 |
Varilutamide
AR antagonist
|
Varilutamide (ONC1-13B) is a potent, nonsteroidal antagonist of androgen receptor, inhibits DHT-induced PSA expression with Ki of 20 nM, fully inhibits androgen-dependent gene expression. |
| PC-26742 |
DALTAC-1
AR-p300/CBP DALTAC
|
DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1) is a specific AR-p300/CBP Domain-ALTeration Chimeras (DALTAC), targets the AR-p300 complex by repurposing their natural interfaces to block activation of the AR oncogenic enhanceosome, selectively suppresses the growth of AR-positive prostate cancer cells. |
| PC-25059 |
AZD3514
AR inhibitor
|
AZD3514 is an orally bioavailable small-molecule androgen receptor downregulator with pIC50 of 5.75, inhibits androgen-dependent and -independent AR signaling. |
| PC-25024 |
Dimethylcurcumin
AR inhibitor
|
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion. |
| PC-24653 |
R9-AR-PIP
PCNA/AR inhibitor
|
R9-AR-PIP is a small peptide mimicking androgen receptor (AR) PIP-box that inhibit the PCNA/AR interaction, inhibits the expression of AR target genes, AR transcriptional activity and the growth of AR-expressing cells, binds to GFP-PCNA with Kd of 2.73 uM in MST assays. |
| PC-24037 |
AP503
GPR133 agonist
|
AP503 (AP-970/43482503) is a potent, specific small molecule agonist of androgen membrane receptor GPR133 (ADGRD1) with EC50 of 1.21 nM. |
| PC-22862 |
AR modulator 1
SARM
|
AR modulator 1 is a potent, selective androgen receptor modulator (SARM). |
| PC-22814 |
EPI-7386
AR NTD inhibitor
|
Masofaniten (EPI-7386) is a next-generation androgen receptor N-terminal domain (AR NTD) inhibitor, inhibits AR activity by binding the N-terminal domain (NTD) and blocking transcription, irrespective of ligand-binding domain resistance mechanisms. |
| PC-22067 |
SC912
AR-V7 inhibitor
|
SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding. |
| PC-22037 |
Bicalutamide
AR antagonist
|
Bicalutamide (ICI 176,334) is an orally active non-steroidal androgen receptor (AR) antagonist for treatment of prostate cancer. |
| PC-21578 |
AR NTD inhibitor 16
AR NTD inhibitor
|
AR NTD inhibitor 16 is a small molecule inhibitor of androgen receptor N-terminal domain (AR NTD) with IC50 of 0.12 uM in VCaP cell-based GRE2-luciferase reporter gene assays. |
| PC-21406 |
UT-155
AR inhibitor
|
UT-155 is a potent and selective androgen receptor (AR) degrader (SARD), binds to AR-LBD (Ki=267 nM), degrades and inhibits AR and AR splice variants (AR-SVs), including AR-V7. |
