ADGRD1 agonist GL64 | GPR133 agonist | Probechem Biochemicals

Chemical Structure : ADGRD1 agonist GL64

加入收藏

ADGRD1 agonist GL64 (GPR133 agonist GL64)

货号: PC-24994Not For Human Use, Lab Use Only.

ADGRD1 agonist GL64 is a selective agonist of ADGRD1/GPR133 with EC50 of 3.98 uM in CRE-luciferase assays in ADGRD1-overexpressing HEK293T cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ADGRD1 agonist GL64 is a selective agonist of ADGRD1/GPR133 with EC50 of 3.98 uM in CRE-luciferase assays in ADGRD1-overexpressing HEK293T cells.
GL64 shows no effect in HEK293T cells overexpressing adhesion GPCRs, such as ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4.
GL64 also does not activate nonadhesion GPCRs, including GPR68, NPFFR1, GPR183, and GPRC5B.
GL64 (10 μM) inhibits the differentiation of male WT BMMs into mature osteoclasts but had no effect on Adgrd1−/− cells, down-regulates the expression levels of osteoclastogenesis-related genes, including Dc-stamp, Acp5, and Nfatc1, during male mouse osteoclast maturation.
GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway.
GL64 (30 mg/kg, i.p.) rescues ovariectomy-induced bone loss and osteoclast hyperactivity in OVX-induced osteoporosis mice.

物理化学性质&存储条件

分子量	509.81
分子式	C27H19Cl3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-2-(3-((2,4-dichlorobenzyl) oxy)phenyl)-2,3-dihydroquinazo lin-4(1H)-one

参考文献

1. He L, et al. Sci Adv. 2025 Jul 11;11(28):eads3829.

ADGRD1 agonist GL64 (GPR133 agonist GL64)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ADGRD1 agonist GL64 (GPR133 agonist GL64)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.