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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Hippo

Request The Product List ofHippo Hippo

Cat. No. Product Name Information
PC-22068

NIBR-LTSi

Lats kinases inhibitor

NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells.
PC-21957

mCLC846

MST1/2 inhibitor

mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively.
PC-21868

UNC-SOB-5-16

STK3 inhibitor

UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.
PC-21862

MST3/4 inhibitor MR30

MST3/4 inhibitor

MST3/4 inhibitor MR30 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 178 nM and 1100 nM for MST3 and MST4, respectively.
PC-21861

MST3/4 inhibitor MR24

MST3/4 inhibitor

MST3/4 inhibitor MR24 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 57 nM and 583 nM for MST3 and MST4, respectively.
PC-21860

aNDR1

NDR1 agonist

aNDR1 (NDR1 agonist) is a specific small-molecule agonist of Nuclear Dbf2-related kinase 1 (NDR1, STK38), specifically inhibits CRPC cells and promotes kinase activity of NDR1.
PC-21627

JA310

MST3 (STK24) inhibitor

JA310 is a potent, highly selective inhibitor of the mammalian sterile 20-like serine/threonine (MST) family member MST3 (STK24) with ITC KD value of 115 nM.
PC-49294

IHMT-MST1-58

MST1 inhibitor

IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
PC-49207

TRULI

Lats kinases inhibitor

TRULI is a small molecule Yap signaling activator, acts as an ATP-competitive inhibitor of Lats kinases in vitro (Lats1 kinase, IC50=0.2 nM, 10 uM ATP), prevents Yap phosphorylation in the cell-based assays with EC50 of 510 nM.
PC-49206

TDI-011536

Lats kinases inhibitor

TDI-011536 is a potent, ATP-competitive inhibitor of Lats kinases with IC50 of 0.76 nM (2 mM ATP) in vitro assays, prevents Yap phosphorylation in the cell-based assays with EC50 of 10 nM.
PC-73093

GA-017

LATS kinase inhibitor

GA-017 (GA017) is a potent, selective, ATP-competitive LATS kinase (LATS1/2) inhibitor with IC50 of 4.10/3.92 nM, respectively, promotes cell growth.
PC-72700

SBP-3264

STK3/4 inhibitor

SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency.

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