| Cat. No. |
Product Name |
Information |
| PC-22068 |
NIBR-LTSi
Lats kinases inhibitor
|
NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells. |
| PC-21957 |
mCLC846
MST1/2 inhibitor
|
mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively. |
| PC-21868 |
UNC-SOB-5-16
STK3 inhibitor
|
UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2. |
| PC-21862 |
MST3/4 inhibitor MR30
MST3/4 inhibitor
|
MST3/4 inhibitor MR30 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 178 nM and 1100 nM for MST3 and MST4, respectively. |
| PC-21861 |
MST3/4 inhibitor MR24
MST3/4 inhibitor
|
MST3/4 inhibitor MR24 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 57 nM and 583 nM for MST3 and MST4, respectively. |
| PC-21860 |
aNDR1
NDR1 agonist
|
aNDR1 (NDR1 agonist) is a specific small-molecule agonist of Nuclear Dbf2-related kinase 1 (NDR1, STK38), specifically inhibits CRPC cells and promotes kinase activity of NDR1. |
| PC-21627 |
JA310
MST3 (STK24) inhibitor
|
JA310 is a potent, highly selective inhibitor of the mammalian sterile 20-like serine/threonine (MST) family member MST3 (STK24) with ITC KD value of 115 nM. |
| PC-49294 |
IHMT-MST1-58
MST1 inhibitor
|
IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM. |
| PC-49207 |
TRULI
Lats kinases inhibitor
|
TRULI is a small molecule Yap signaling activator, acts as an ATP-competitive inhibitor of Lats kinases in vitro (Lats1 kinase, IC50=0.2 nM, 10 uM ATP), prevents Yap phosphorylation in the cell-based assays with EC50 of 510 nM. |
| PC-49206 |
TDI-011536
Lats kinases inhibitor
|
TDI-011536 is a potent, ATP-competitive inhibitor of Lats kinases with IC50 of 0.76 nM (2 mM ATP) in vitro assays, prevents Yap phosphorylation in the cell-based assays with EC50 of 10 nM. |
| PC-73093 |
GA-017
LATS kinase inhibitor
|
GA-017 (GA017) is a potent, selective, ATP-competitive LATS kinase (LATS1/2) inhibitor with IC50 of 4.10/3.92 nM, respectively, promotes cell growth. |
| PC-72700 |
SBP-3264
STK3/4 inhibitor
|
SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. |
