| Cat. No. |
Product Name |
Information |
| PC-26333 |
Licancopan
Factor B inhibitor
|
Licancopan (HRS-5965) is a potent, selective and orally active complement factor (Factor B) inhibitor, disrupts the formation of C3 convertases within the alternative pathway, thereby halting C3 cleavage and downstream complement activation. |
| PC-26322 |
Ciprocopan
Factor B inhibitor
|
Ciprocopan (NXP100, NXP-100) is a potent, selecticve and oral complement factor B inhibitor. |
| PC-25605 |
Pegcetacoplan
Complement C3 inhibitor
|
Pegcetacoplan (APL-2) is a pegylated complement C3 inhibitor peptide, acts by binding with complement component 3 (C3) and its activation fragment C3b, inhibits classical and alternative pathways. |
| PC-25056 |
Izicopan
C5aR1 antagonist
|
Izicopan (INF056) is a potent, selective complement factor C5a receptor (C5aR1) antagonist with IC50 of <10 nM. |
| PC-24548 |
BCX9930
Factor D inhibitor
|
BCX9930 (Pelecopan) is a potent, selective oral inhibitor of complement Factor D with IC50 of 14.3 nM (purified human factor D), inhibits the activation of the complement alternative pathway (AP). |
| PC-24490 |
Zilucoplan
Complement C5 inhibitor
|
Zilucoplan (RA101495) is a potent, selective macrocyclic peptide inhibitor of complement C5, binds to C5 with high affinity and specificity, prevents the cleavage of C5 into complement components C5a and C5b. |
| PC-21586 |
C1s inhibitor A1
C1s inhibitor
|
C1s inhibitor A1 is a selective, competitive inhibitor of complement component C1s with binding Kd of 9.8 uM, competitively inhibits its activity with Ki of 5.8 uM. |
| PC-20806 |
NSC33353
C5a receptor inhibitor
|
NSC33353 (NSC 33353) is a small molecule inhibitor with potent anti-tumor activity against TNBC cells, enhances TNBC sensitivity to doxorubicin, also is an inhibitor of C5a receptor binding. |
| PC-20173 |
Sepimostat
Multi-protease inhibitor
|
Sepimostat (FUT-187) is a potent multi-protease inhibitor with IC50 of 0.097 uM for trypsin, 0.029 uM for pancreatic kallikrein, 0.61 uM for plasma kallikrein, 0.57uM for plasmin, 2.5 uM for thrombin, 20.4 uM for factor Xa and 6.4 uM for C1r. |
| PC-38846 |
W54011
C5aR antagonist
|
W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM. |
| PC-38845 |
PMX205
C5aR antagonist
|
PMX205 (PMX-205) is a potent, selective C5a receptor (C5aR) peptide antagonist with IC50 of 30 nM. |
| PC-38358 |
Vemircopan
Factor D inhibitor
|
Vemircopan (ALXN2050, ACH 5228) is a second generation, orally active complement factor D inhibitor, has the potential to decrease disease symptoms and increase strength in generalized myasthenia gravis (gMG). |
