| Cat. No. |
Product Name |
Information |
| PC-27577 |
PinA1
CK1⍺ degrader
|
PinA1 is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27547 |
dACSL4
ACSL4 degrader
|
dACSL4 is a potent, selective PROTAC degrader targeting ACSL4 (DC50=103 nM, SH-SY5Y cells) by conjugating troglitazone to the CRBN-binding ligand pomalidomide, concurrently degrades ACSL4 and activates PPARγ signaling. |
| PC-27503 |
Sovutrecdeg
TRK degrader
|
Sovutrecdeg (CG001419) is a first-in-class, selective, potent oral degrader of pan-tropomyosin receptor kinase (TRK), selectively degrades both mutant and wild-type TRK proteins. |
| PC-27493 |
Reziciclideg
CDK4/6 degrader
|
Reziciclideg (BTX-9341) is a potent, seletive, blood-brain barrier permeable cereblon-mediated bifunctional degrader of CDK4 and CDK6 with Kd of 31 nM (CDK6). |
| PC-27488 |
SIAIS164018 hydrochloride
Multi-kinases PROTAC
|
SIAIS164018 hydrochloride is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27487 |
SIAIS164018
Multi-kinases PROTAC
|
SIAIS164018 is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27486 |
Omtebrutideg
BTK PROTAC
|
Omtebrutideg is a potent and selective BTK PROTAC degrader. |
| PC-27298 |
SK-575
PARP1 PROTAC
|
SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. |
| PC-27186 |
dIRF4-2
IRF4 PROTAC
|
dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h). |
| PC-27030 |
dCBP-30
CBP/p300 degrader
|
dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300). |
| PC-26928 |
XYD224
BRD9 degrader
|
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells. |
| PC-26772 |
MRT-5702
G3BP2 molecular glue degrader
|
MRT-5702 is a specific molecular glue degrader of G3BP2 targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
