| Cat. No. |
Product Name |
Information |
| PC-28743 |
GT-01956
GSPT1 degrader
|
GT-01956 is a potent, selective BET-targeting PROTAC degrader with picomolar degradation potency, shows exceptional anti-proliferative activity across hematologic and solid tumor cell lines. |
| PC-28742 |
GT-02624
GSPT1 degrader
|
GT-02624 is a potent, selective GSPT1 molecular glue degrader, shows degradation selectivity over canonical CRBN neosubstrates and corresponding anti-proliferative activity. |
| PC-28734 |
DZ-837
BCL6 degrader
|
DZ-837 is an effective BCL6-targeting PROTAC degrader with DC50 values around 600 nM in SU-DHL-4 and DOHH2 cells, effectively inhibits cell growth in BCL6-dependent DLBCL cell lines, exhibits synergistic antiproliferative response and overcame acquired resistance against DLBCL cells combined with Ibrutinib. |
| PC-28733 |
BCL6/GSPT1 degrader A5
BCL6/GSPT1 degrader
|
BCL6/GSPT1 degrader A5 is an effective, dual BCL6/GSPT1 degrader with DC50 of 0.48 nM (BCL6) in Farage cells, demonstrates excellent antiproliferative effects across multiple lymphoma cell lines (Farage cells, IC50=0.413 uM), induces DNA damage, cell cycle arrest and apoptosis. |
| PC-28730 |
DN1679
CDK12/13 degrader
|
DN1679 is a potent, orally bioavailable, and highly selective CDK12/13 dual degrader with DC50 of 8.8/9.8 nM, suppresses TNBC growth both in vitro and in vivo. |
| PC-28729 |
MS479
BRD4 PROTAC
|
MS479 is a specific SPOP-recruiting BRD4 PROTAC degrader with DC50 of 6.2 uM, recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein, effectively reduces the protein level of BRD4 short isoform (BRD4 (S)) in a time-, concentration-, GLP-, SPOP-, and ubiquitin-proteasome system (UPS)-dependent manner. |
| PC-28728 |
BRD3 PROTAC D072
BRD3 degrader
|
BRD3 PROTAC D072 is a specific BRD3 degrader, shows potential anti-inflammatory effect in microglia. |
| PC-28726 |
AZD9750
AR degrader
|
AZD9750 is a potent, selective and orally bioavailable Androgen Receptor (AR) PROTAC degrader with DC50 of 10 nM and 12 nM for AR WT and AR L702H respectively. showed extensive degradation of AR, including L702H AR (Dmax >100%). |
| PC-28725 |
RNK06395
ERK5 degrader
|
RNK06395 is a potent orally available chaperone-mediated ERK5 degrader (Chaperone-Mediated Protein Degradation, ERK5-CHAMP), degrades ERK5 protein in Huh-7 (Dmax=71.3%, DC50 of 50.98 nM), MOLP-8 (Dmax=84.7%, DC50=24.54 nM). |
| PC-28723 |
PINAD-1
MALAT1 degrader
|
PINAD-1 is a first-in-class small molecule that selectively induces the degradation of MALAT1 with Kd of 2.5 uM, achieving an 85% reduction in MALAT1 transcript levels at 5 uM on MCF-7 cells, induces specific cleavage of the MALAT1 transcript in vitro and in cellulo. |
| PC-28712 |
ZX079
BRD4/CBP PROTAC
|
ZX079 is a potent, selective dual BRD4/CBP PROTAC degrader with DC50 of 0.035 nM and <0.02 nM in MV4-11 cells. |
| PC-28662 |
DIX-01
IKZF1/3 and GSPT1 degrader
|
DIX-01 is a potent dual IKZF1/3 and GSPT1 molecular glue degrader with DC50 values of 19.80 nM for IKZF1, 45.31 nM for IKZF3, and 120.1 nM for GSPT1 in MV4-11 cells. |
