| Cat. No. |
Product Name |
Information |
| PC-24668 |
BMS-986458
BCL6 degrader
|
BMS-986458 is a potent, highly selective, orally bioavailable CRL4 CRBN E3 ubiquitin ligase-dependent BCL6 ligand directed degrader. |
| PC-24667 |
PRT3789
SMARCA2 degrader
|
PRT3789 is a first-in-class potent and selective SMARCA2 (BRM) degrader with DC50 of 0.72 nM in Hela cells, effectively catalyze the polyubiquitination of specific lysine residues of SMARCA2, resulting in SMARCA2 selective degradation over SMARCA4. |
| PC-24664 |
BMS-986449
IKZF2/4 degrader
|
BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4). |
| PC-24663 |
GDC-2992
AR PROTAC
|
GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells. |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
| PC-24575 |
RP03707
KRAS G12D PROTAC
|
RP03707 is a CRBN-involving, highly potent, and selective KRAS G12D PROTAC degrader with DC50 of 0.7 nM in PK-59 cells (Dmax=96%). |
| PC-24558 |
MNK1 PROTAC P11-2
MNK1 PROTAC
|
MNK1 PROTAC P11-2 is a first-in-class, selective MNK1-targeting PROTAC degrader with DC50 of 11.92 nM (MV4-11 cells), Dmax>96%, shows remarkable selectivity for MNK1 over MNK2. |
| PC-24557 |
ERD-1233
ERα degrader
|
ERD-1233 is a potent and orally efficacious PROTAC degrader of estrogen receptor α (ERα) with DC50 of 0.9 nM in MCF-7 cell line, Dmax=100%. |
| PC-24555 |
PLX-4545
IKZF2 degrader
|
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity. |
| PC-24554 |
PVTX-405
IKZF2 degrader
|
PVTX-405 is a potent, highly selective, rapid and orally efficacious CRBN-dependent glue degrader of IKZF2 with DC50 of 0.7 nM in IKZF2 HiBiT degradation assay in HEK293 cells, Dmax = 91%. |
| PC-24551 |
BD-9136
BRD4 degrader
|
BD-9136 is a potent, highly selective PROTAC degrader of BRD4 with DC50 of 1.2 nM (MV-4-11 cell, 4 h), Dmax=99%, displays >1000-fold selective over BRD2 and BRD3 proteins. |
| PC-24506 |
LZK PROTAC 17
LZK degrader
|
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM. |
