| Cat. No. |
Product Name |
Information |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-27121 |
SMD-1087
SMARCA2 PROTAC
|
SMD-1087 is a highly potent, selective SMARCA2 PROTAC degrader with DC50 of 9 nM, with limited activity against SMARCA4. |
| PC-27120 |
SMD-6346
SMARCA2 PROTAC
|
SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%). |
| PC-27096 |
HDAC6 PROTAC 15
HDAC6 PROTAC
|
HDAC6 PROTAC 15 is a potent, selective HDAC6 degrader with pDC50 of 9.1 in bronchial epithelium cells, reduces α-tubulin hyperacetylation without affecting histone-3 acetylation. |
| PC-27068 |
JNJ-1013
IRAK1 PROTAC
|
JNJ-1013 is a highly potent, selective interleukin-1 receptor-associated kinase 1 (IRAK1) PROTAC degrader with DC50 of 3 nM in HBL-1 cells, Dmax=96%. |
| PC-27030 |
dCBP-30
CBP/p300 degrader
|
dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300). |
| PC-26979 |
R4VP
RNF4 degrader
|
R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells. |
| PC-26978 |
CCW 28-3
BRD4 PROTAC
|
CCW 28-3 is a bifunctional BRD4 PROTAC degrader linking RNF4 ligand CCW16 to BET bromodomain family inhibitor JQ1, degrades BRD4 in a proteasome- and RNF4-dependent manner. |
| PC-26976 |
R4VPL3-1
RNF4 degrader
|
R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells. |
| PC-26975 |
RNF4 PROTAC RD12
RNF4 degrader
|
RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage. |
| PC-26926 |
M9101
Aurora A PROTAC
|
M9101 is a potent, selective and in vivo active Aurora A PROTAC degrader with DC50 value of 2.3 nM in MD-MBA-231 cells. |
