| Cat. No. |
Product Name |
Information |
| PC-26219 |
XYD270
BRD9 PROTAC
|
XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively. |
| PC-26139 |
KTX-951
IRAK4 PROTAC
|
KTX-951 is a potent and orally active degrader of IRAK4 and the Ikaros and Aiolos (IMiD) substrates with DC50 of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively, induces proteasomal degradation of these key proteins, leading to the dual inhibition of the NF-κB and IRF4 signaling pathways. |
| PC-26138 |
KTX-582
IRAK4 PROTAC
|
KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model. |
| PC-26133 |
GDCNF-11
GPX4 degrader
|
GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM. |
| PC-26131 |
GDAz-3
GPX4 degrader
|
GDAz-3 is a potent GPX4-targeting HSP70-PROTAC, potently and rapidly eliminates GPX4 in HT1080 cells (DC50=0.13 uM), thereby triggering ferroptosis with high selectivity. |
| PC-26015 |
CCT400028
Aurora A PROTAC
|
CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling. |
| PC-25972 |
WWZ-11-098
CDK6 degrader
|
WWZ-11-098 is a potent, selective Palbociclib-based CDK6 degrader with DC50 of 2.6 nM and Dmax of 99.9 % in MOLT4 cells via CRBN-dependent manner, while sparing CDK1, CDK2, CDK4, and CDK9. |
| PC-25951 |
NP1192
NAT10 PROTAC
|
NP1192 is a highly effective PROTAC degrader targeting NAT10, promotes NAT10 KD and inhibits ac4C modification, facilitates NAT10 degradation through the ubiquitin-proteasome system (UPS). |
| PC-25907 |
CPD-2828
IRE1α PROTAC
|
CPD-2828 is the first PROTAC degrader of IRE1α with DC50 of 0.43 uM in HEK293T cell, exhibits CRBN binding IC50 of 0.65 uM. |
| PC-25892 |
CDK6 PROTAC 48a
CDK6 PROTAC
|
CDK6 PROTAC 48a is a potent, selective, KLHDC2-mediated CDK6 PROTAC degrader with DC50 of 37 nM in MOLM-14 cells, selectively degrades CDK6 among 8642 proteins and within the CDK family. |
| PC-25887 |
PLK4 PROTAC SP27
PLK4 PROTAC
|
PLK4 PROTAC SP27 is a potent, selective PLK4 proteolysis targeting chimera (PROTAC) degrader with binding IC50 of 8.4 nM for PLK4, DC50 of 19.5 nM in MCF-7 cells. |
| PC-25872 |
dCDK9-202
CDK9 PROTAC
|
dCDK9-202 is a highly potent, selective PROTAC CDK9 degrader with DC50 of 3.5 nM and CDK9 decline (94.4%) at 25 nM in TC-71 cell line, inhibits cell growth with IC50 of 8.5 nM in TC-71 cells. |
