| Cat. No. |
Product Name |
Information |
| PC-49045 |
MD-224
MDM2 PROTAC
|
MD-224 is a small-molecule MDM2 degrader based on the proteolysis targeting chimera (PROTAC), effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. |
| PC-49044 |
ARD-69
AR PROTAC
|
ARD-69 is a highly potent PROTAC degrader of androgen receptor (AR), effectively induces degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1 with DC50 values of 0.86, 0.76, and 10.4 nM, respectively. |
| PC-47084 |
JCS-1
DcpS PROTAC
|
JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines. |
| PC-47018 |
ZXH-1-161
GSPT1 PROTAC
|
ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM. |
| PC-47017 |
SJ6986
GSPT1/2 PROTAC
|
SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively. |
| PC-38903 |
U7D-1
USP7 PROTAC
|
U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC) with DC50 of 33 nM in RS4;11 cells. |
| PC-38738 |
Degradomer D-1
IRAK3 PROTAC
|
Degradomer D-1 is a selective proteasomal degrader of IRAK3 with Kd of 100 nM, DC50 of 94 nM, displays no binding affinity against IRAK4 (Ki >10 uM). |
| PC-38718 |
CRBN(BRAF)-24
BRAF V600E PROTAC
|
CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells. |
| PC-38566 |
STING PROTAC SP23
STING PROTAC
|
SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM. |
| PC-38462 |
dBRD9 dihydrochloride
BRD9 PROTAC
|
dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells. |
| PC-73343 |
YX-2-115
CDK6 inhibitor
|
YX-2-115 is a palbociclib derivative compound with piperazine-linker tail for PROTAC YX-2-107 synthesis, inhibits CDK6 with IC50 of 4.5 nM. |
| PC-73342 |
YX-2-107
CDK6 PROTAC
|
YX-2-107 is a CRBN-recruiting and specific CDK6-degrading PROTAC with IC50 of 0.69 and 4.4 nM for CDK4 and CDK6 in vitro, selectively degardes CDK6 in Ph+ BV173 ALL cells with a degradation constant of 4 nM. |
