| Cat. No. |
Product Name |
Information |
| PC-24265 |
HDAC6 PROTAC 17c
HDAC6 PROTAC
|
HDAC6 PROTAC 17c is a potent, selective CRBN- and VHL-recruiting PROTAC degrader of HDAC6 with DC50 of 14 nM in MM.1S cells, Dmax of 91%, high selective over other HDACs. |
| PC-24242 |
BT-O2C
p300 PROTAC
|
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM). |
| PC-24233 |
PP-C8
CDK12 PROTAC
|
PP-C8 is a potent, selective CDK12-cyclin K complex PROTAC degrader with DC50 of DC50 of 416 nM and 412 nM for CDK12 and CycK protein levels respectively, does not affect CDK13. |
| PC-24107 |
ANXA3 degrader 18a5
ANXA3 degrader
|
ANXA3 degrader 18a5 is a highly selective ANXA3 degrader with SPR KD of 0.08 uM, exhibits antiproliferative activity against with IC50 of 0.71 and 1.05 uM, DC50 of 3.12 uM and 1.32 uM in MDA-MB-468 and MDA-MB-231 cells, respectively. |
| PC-24083 |
SK2188
Aurora A PROTAC
|
SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN. |
| PC-24082 |
JB170
Aurora A PROTAC
|
JB170 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 28 nM and Dmax of 300 nM in MV4-11 cells, linking alisertib to the cereblon-binding molecule Thalidomide. |
| PC-24081 |
JB300
Aurora A PROTAC
|
JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM. |
| PC-24047 |
KT-333
STAT3 degrader
|
KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines. |
| PC-24046 |
CDK9 PROTAC C3
CDK9 degrader
|
CDK9 PROTAC C3 is a potent and selective, oral CDK9 PROTAC degrader with DC50 of 1.09 nM in NCI-H69 cells. |
| PC-24021 |
NRX-0492
BTK PROTAC
|
NRX-0492 is a potent, selective cereblon (CRBN)-basesd PROTAC degrader of wild-type and C481 mutant BTK with DC50 of 0.1 nM and 0.2 nM, and DC90 of 0.3 nM and 0.5 nM in TMD8 cells expressing WT or C481S mutant BTK respectively. |
| PC-23960 |
QXG-6442
CK1α PROTAC
|
QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells. |
| PC-23948 |
TD-522
GSPT1 degrader
|
TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells. |
