| Cat. No. |
Product Name |
Information |
| PC-27488 |
SIAIS164018 hydrochloride
Multi-kinases PROTAC
|
SIAIS164018 hydrochloride is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27487 |
SIAIS164018
Multi-kinases PROTAC
|
SIAIS164018 is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis. |
| PC-27486 |
Omtebrutideg
BTK PROTAC
|
Omtebrutideg is a potent and selective BTK PROTAC degrader. |
| PC-27441 |
YTHDC1 PROTAC XY-2
YTHDC1 degrader
|
YTHDC1 PROTAC XY-2 is a selective, efficient PROTAC degrader of N6-Methyladenosine (m6A) reader YTHDC1 with DC50 of 11.42 nM in MOLM13 and 13.59 nM in Kasumi-1 cells respectively. |
| PC-27298 |
SK-575
PARP1 PROTAC
|
SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. |
| PC-27186 |
dIRF4-2
IRF4 PROTAC
|
dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h). |
| PC-27030 |
dCBP-30
CBP/p300 degrader
|
dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300). |
| PC-26928 |
XYD224
BRD9 degrader
|
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells. |
| PC-26772 |
MRT-5702
G3BP2 molecular glue degrader
|
MRT-5702 is a specific molecular glue degrader of G3BP2 targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
| PC-26648 |
LD5095
RIPK1 PROTAC
|
LD5095 is a potent, selective cereblon (CRBN)-recruiting RIPK1 degrader with DC50 of 1.4, 1.2, and 2.3 nM and Dmax>90% for endogenous RIPK1 in WT Jurkat, MOLM14, and U937 cell lines. |
| PC-26588 |
TNG961
HBS1L degrader
|
TNG961 (TNG-961) is a potent, selective and oral CRBN-dependent HBS1L (GSPT3) molecular glue degrader with DC50 of 7 nM and Dmax of 98%, does not affect closely related GSPT1 protein, disrupts the HBS1L/PELO complex. |
| PC-26498 |
Cyclin D1 degrader MS28
Cyclin D1 degrader
|
Cyclin D1 degrader MS28 (XY028-133) is a potent, selective and first-in-class PROTAC degrader of cyclin D1 through recruiting the CDK4/6-cyclin D1 complex to VHL E3 ligase, effectively degrades cyclin D1 in Calu-1 cells with DC50 of 950 nM and Dmax of 90% (8 h). |
