| Cat. No. |
Product Name |
Information |
| PC-26979 |
R4VP
RNF4 degrader
|
R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells. |
| PC-26978 |
CCW 28-3
BRD4 PROTAC
|
CCW 28-3 is a bifunctional BRD4 PROTAC degrader linking RNF4 ligand CCW16 to BET bromodomain family inhibitor JQ1, degrades BRD4 in a proteasome- and RNF4-dependent manner. |
| PC-26898 |
PLX-4104
BRD4 degrader
|
PLX-4104 is a potent, selective monovalent DCAF11-acting degrader of BRD4 with DC50 of 2 nM and Dmax of >95% in MV411 cells (24 h), shows antiproliferative activity with IC50 of 4 nM on MV-4-11 cells. |
| PC-26810 |
NK250
USP7 PROTAC
|
NK250 is a potent, selective, Cullin-Ring-E3 ligase (CRL)-dependent USP7 PROTAC degrader with DC50 of 4 nM in MV4-11 cells (24 h). |
| PC-26773 |
MRT-5702D
G3BP2 molecular glue degrader
|
MRT-5702D is a specific molecular glue degrader targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
| PC-26692 |
M4K3250
ALK2 degrader
|
M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.9 in HEK-293 cells and Dmax=78%, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway. |
| PC-26691 |
M4K3233
ALK2 degrader
|
M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.3 in HEK-293 cells, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway. |
| PC-26688 |
Polθ degrader 1
DNA Polθ degrader
|
Polθ degrader 1 is a potent efficient degrader of DNA polymerase theta (Polθ). |
| PC-26578 |
BMS-986482
IKZF1-4 degrader
|
BMS-986482 is a rapid, selective, CRBN-dependent pan-degrader of IKZF transcription factor family members, induces robust tumor growth inhibition. |
| PC-26534 |
TKP-5
BRD4 degrader
|
TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression. |
| PC-26524 |
MGD-28
IKAROS protein degrader
|
MGD-28 is a potent, orally active CRBN-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), also degrades CK1α (DC50=7.8 nM). |
| PC-26523 |
PVTX-321
ERα degrader
|
PVTX-321 is a potent and orally bioavailable estrogen receptor α (ERα) heterobifunctional degrader with DC50 of 0.15 nM, Dmax = 81% in MCF7 cells. |
