| Cat. No. |
Product Name |
Information |
| PC-72309 |
DGY-09-192
FGFR degrader
|
DGY-09-192 is a bivalent degrader (PROTAC) that couples the pan-FGFR inhibitor BGJ398 to a CRL2VHL E3 ligase recruiting ligand,preferentially induces FGFR1/2 degradation while largely sparing FGFR3/4. |
| PC-72308 |
HPK1 PROTAC SS47
HPK1 degrader
|
HPK1 PROTAC SS47 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1. |
| PC-72307 |
HPK1 PROTAC SS44
HPK1 degrader
|
HPK1 PROTAC SS44 is a heterobifunctional small molecule HPK1 PROTAC degrader based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1. |
| PC-72286 |
MS177
EZH2 PROTAC
|
MS177 (MS-177) is a potent and selective EZH2 degarder (PROTAC) based on EZH2 inhibitor C24 with CRBN ligand pomalidomide with DC50 of 0.2 uM in EOL-1 cells. |
| PC-72115 |
CG428
Trk PROTAC
|
CG428 (CG-428) is a first-in-class potent and selective TRK degrader (PROTAC) with DC50 of 0.36 nM. |
| PC-72092 |
YZ268
HDAC6 PROTAC
|
HDAC6 Degrader 13f (YZ268) is a selective HDAC6 degrader (PROTAC) with high potency, specific chemical probe to knock-down HDAC6. |
| PC-38303 |
Helios degrader ALV2
Helios degrader
|
Helios degrader ALV2 (ALV-04-019-01) is a potent and selective Helios degrader with IC50 of 0.57 uM in CRBN-binding TR-FRET assay. |
| PC-38302 |
Helios degrader ALV1
Helios degrader
|
Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay, exhibits similar degradation activity towards IKZF1/2/3. |
| PC-38300 |
MS1943
EZH2 PROTAC
|
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM. |
| PC-38232 |
DDC-01-163
EGFR PROTAC
|
DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected. |
| PC-38185 |
SHP2-D26
SHP2 PROTAC
|
SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4. |
| PC-38182 |
SHP2 PROTAC R1-5C
SHP2 PROTAC
|
SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50. |
