| Cat. No. |
Product Name |
Information |
| PC-22750 |
BSJ-5-63
CDK12/7/9 PROTAC
|
BSJ-5-63 is a potent, triple PROTAC degrader targeting cyclin-dependent kinases (CDKs) CDK12, CDK7, and CDK9, downregulates HRR genes and inhibits AR signaling. |
| PC-22748 |
G9a degrader G9D-4
G9a PROTAC
|
G9D-4 is a first-in-class, potent, selective PRTOAC degrader of protein lysine methyltransferase G9a (EHMT2, KMT1C) with DC50 of 0.1 uM in PANC-1 cells, highly selective over GLP (DC50>10 uM). |
| PC-22688 |
CP134
DYRK2 PROTAC
|
CP134 is a potent, selective PROTAC degrader of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with DC50 of 1.6 uM in MM231 and 3.3 uM in HeLa, respectively. |
| PC-22612 |
BRD9 PROTAC E5
BRD9 PROTAC
|
BRD9 PROTAC E5 is a highly potent, selective BRD9 PROTAC degrader with DC50 of 16 pM, IC50 of 0.27 nM for antiproliferation in MV4-11 cells. |
| PC-22591 |
UNC8153 TFA
NSD2 PROTAC
|
UNC8153 (UNC 8153) TFA is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark. |
| PC-22590 |
UNC10088
NSD2 degrader
|
UNC10088 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22588 |
UNC8732
NSD2 degrader
|
UNC8732 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, SPR KD of 76 nM, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22586 |
dWIZ-2
WIZ degrader
|
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts. |
| PC-22578 |
XZ9002
HDAC3 degrader
|
XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells. |
| PC-22535 |
KI-CDK9d-32
CDK9 degrader
|
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels. |
| PC-22429 |
R1-ICR-5
RIPK1 PROTAC
|
R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis |
| PC-22394 |
MS140
CDK4/6 PROTAC
|
MS140 (XY028-140) is a potent and selective, CRBN-dependent CDK4/6-degrader (PROTAC) with IC50 of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, suppresses Rb/E2F signaling and reduces CDK4 and CDK6 protein levels. |
