| Cat. No. |
Product Name |
Information |
| PC-25335 |
ABS-752 hydrochloride
GSPT1/NEK7 degrader
|
ABS-752 hydrochloride is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25326 |
JWJ-01-368
ZBTB11 degrader
|
JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation. |
| PC-25325 |
JWJ-01-306
ZBTB11 degrader
|
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells. |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-24975 |
SD-91
STAT3 PROTAC degrader
|
SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line. |
| PC-24854 |
YTHu78
KDM5B PROTAC
|
YTHu78 is a potent, selective CRBN ligand-based KDM5B PROTAC degrader, effectively induce KDM5B degradation in MV-4-11 and MM.1S cell lines, exhibits comparable degradation efficacy toward KDM5B and KDM5A. |
| PC-24668 |
BMS-986458
BCL6 degrader
|
Toviblideg (BMS-986458) is a potent, highly selective, orally bioavailable CRL4 CRBN E3 ubiquitin ligase-dependent BCL6 ligand directed degrader with CRBN binding IC50 of 41 nM, and BCL-6 degradation of 0.2 nM in OCI-LY-1 cells (2 h). |
| PC-24667 |
PRT3789
SMARCA2 degrader
|
PRT3789 is a first-in-class potent and selective SMARCA2 (BRM) degrader with DC50 of 0.72 nM in Hela cells, effectively catalyze the polyubiquitination of specific lysine residues of SMARCA2, resulting in SMARCA2 selective degradation over SMARCA4. |
| PC-24664 |
BMS-986449
IKZF2/4 degrader
|
BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors IKZF2 (Helios) and IKZF4 (Eos). |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader (DC50<40 nM in THP-1 cells), effectively degrades LSD1 in a concentration-, time-, and proteasome-dependent manner. |
