SD-965 | STAT3 PROTAC | Probechem Biochemicals

Chemical Structure : SD-965

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SD-965 (SD965)

货号: PC-26447Not For Human Use, Lab Use Only.

SD-965 is a potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 0.14 uM and Dmax = 85%, inhibits cell growth of MOLM-16 leukemia cell line with IC50 of 1.3 nM.

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生物&药学活性

SD-965 is a potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 0.14 uM and Dmax = 85%, inhibits cell growth of MOLM-16 leukemia cell line with IC50 of 1.3 nM.

物理化学性质&存储条件

分子量	1213.22
分子式	C56H65N10O17PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(((5S,8S,10aR)-8-(((S)-5-Amino-1-(3-(methylsulfonyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-(6-((R)-2-((S)-2,6-dioxopiperidin-3-yl)-1-oxo-2,3,5a,6,8,9-hexahydro-1H-pyrazino[1',2':4,5][1,4]oxazino[2,3-e]isoindol-7(5H)-yl)-6-oxohexanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indole-5-carbonyl)phosphonic Acid

参考文献

1. Wu D, et al. J Med Chem. 2026 Mar 23. doi: 10.1021/acs.jmedchem.5c03767.

SD-965 (SD965)

生物&药学活性

物理化学性质&存储条件

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SD-965 (SD965)

生物&药学活性

物理化学性质&存储条件

参考文献

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