GDCNF-11 | GPX4 degrader | Probechem Biochemicals

Chemical Structure : GDCNF-11

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GDCNF-11 (GDCNF11)

货号: PC-26133Not For Human Use, Lab Use Only.

GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM.

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生物&药学活性

GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM.
GDCNF-11 showed 15-fold more ferroptosis selectivity over GPX4 inhibitor ML162.
GDCNF-11 effectively suppress tumor growth in the mice model with relatively low toxicity as compared to the combination therapy of GPX4 and HSP90 inhibitors.

物理化学性质&存储条件

分子量	995.00
分子式	C48H53Cl2N13O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiopheneacetamide, α-[[4-[[1-[2-[4-[2-[[2-amino-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-6-yl]amino]ethyl]-1-piperidinyl]-2-oxoethyl]-1H-1,2,3-triazol-4-yl]methoxy]-3-chlorophenyl](2-chloroacetyl)amino]-N-(2-phenylethyl)-

参考文献

1. Jinyun Dong, et al. J Med Chem. 2024 Sep 26;67(18):16712-16736.

GDCNF-11 (GDCNF11)

生物&药学活性

物理化学性质&存储条件

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GDCNF-11 (GDCNF11)

生物&药学活性

物理化学性质&存储条件

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