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首页-抗体药物偶连体和PROTACs-PROTAC-CCT400028
CCT400028

Chemical Structure : CCT400028

CAS No.:

CCT400028 (CCT-400028)

货号: PC-26015Not For Human Use, Lab Use Only.

CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling.

    物理化学性质&存储条件

    分子量 878.40
    分子式 C47H49ClFN7O7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-N-(5-((5-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenoxy)pentyl)oxy)pentyl)-2-methoxybenzamide

    参考文献

    1. O'Hanlon JA, et al. J Med Chem. 2026 Jan 22;69(2):1552-1567.

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