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首页-抗体药物偶连体和PROTACs-PROTAC-Orevandrodeg
Orevandrodeg

Chemical Structure : Orevandrodeg

CAS No.: 2756845-16-4

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Orevandrodeg (BMS-986460, BMS986460, CC-2043137, CC2043137)

货号: PC-26347Not For Human Use, Lab Use Only.

Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer.

物理化学性质&存储条件

分子量 811.93
分子式 C39H48F3N9O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,6S)-4-[2-[[trans-4-[3-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]cyclohexyl]oxy]ethyl]-N-[3-[[(3S)-2,6-dioxo-3-piperidinyl]amino]phenyl]-2,6-dimethyl-1-piperazineacetamide

参考文献

1. Patent WO2021262810 A1.

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