| Cat. No. |
Product Name |
Information |
| PC-26461 |
CXJ2080
CDK7 PROTAC
|
CXJ2080 is a potent, selective CDK7 PROTAC degrader with DC50 of 0.88 nM and Dmax >98% in MV4-11 cells, disrupts the CDK7-cyclin H-MAT1 complex, simultaneously suppressing MYC-driven oncogenic signaling while activating the p53-p21 tumor suppressor axis. |
| PC-26457 |
KRAS G12C PROTAC LC-2
KRAS G12C PROTAC
|
KRAS G12C PROTAC LC-2 is a potent, selective VHL-Recruiting PROTAC degrader of KRASG12C with DC50 of 0.59 uM and Dmax of 80% in NCI-H2030 cells. |
| PC-26447 |
SD-965
STAT3 PROTAC
|
SD-965 is a potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 0.14 uM and Dmax = 85%, inhibits cell growth of MOLM-16 leukemia cell line with IC50 of 1.3 nM. |
| PC-26417 |
WCF-598
RXRγ PROTAC
|
WCF-598 (WCF598) is a potent, selective RXRγ PROTAC degrader with DC50 of 24.82 nM and 27.15 nM in 22Rv1 and VCaP-CRPC cells respectively. |
| PC-26404 |
MLKL PROTAC C116
MLKL PROTAC
|
MLKL PROTAC C116 is a potent and selective MLKL degrader with DC50 of 248.9 nM in Hepa1-6 cells and 271.3 nM in HepG2 cells, Dmax of 99.3% and 91.2% respectively. |
| PC-26385 |
JP-2-197
BRD4 degrader
|
JP-2-197 is a fumarate-based RNF126-dependent BRD4 degrader, induces robust degradation of both long and short BRD4 isoforms in RNF126 wild-type cells but not in RNF126 knockout cells. |
| PC-26370 |
HDAC3 degrader GS-1
HDAC3 degrader
|
GS-1 is a potent, selective HDAC3 degrader with DC50 of 1.24 uM in THP-1 cells, shows minimal degradation of HDAC1 or HDAC2 at 5 uM. |
| PC-26347 |
Orevandrodeg
Ligand-directed degrader
|
Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer. |
| PC-26284 |
DZ-865B
BCL6 PROTAC
|
DZ-865B is a selective BCL6 degrader with DC50 of 2.7 uM and 4.7 uM in DLBCL cell lines OCI-LY-1 and SU-DHL-4 respectively, effectively suppresses DLBCL cell growth. |
| PC-26247 |
DFCI-002-06
HCK/BTK PROTAC
|
DFCI-002-06 is a potent, first-in-class dual HCK/BTK PROTAC degrader with DC50 values of 4.5 nM for BTK and 1.3 nM for HCK, Dmax values of >95% for BTK and 87% for HCK. |
| PC-26238 |
USP39_PROTAC_V1
USP39 PROTAC
|
USP39_PROTAC_V1 is a potent, selective VHL‐based PROTAC degrader of USP39 with KD of 232 nM, DC50 of 1 nM in HeLa cells. |
| PC-26228 |
ITRI-148
AR-NTD PROTAC
|
ITRI-148 is a CRBN-based androgen receptor N-terminal domain (AR-NTD) degrader, degrades AR, AR-V7, and AR mutants with DC50 of 0.05 uM and 0.02 uM for AR and AR-V7in VCaP cells. |
