SJ6986 | GSPT1/2 PROTAC | Probechem Biochemicals

Chemical Structure : SJ6986

CAS No.: 2765625-93-0

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SJ6986 (SJ 6986, SJ-6986)

货号: PC-47017Not For Human Use, Lab Use Only.

SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively.
SJ6986 displays selectivity over classical IMiD neosubstrates, such as IKZF1/3.
SJ6986 is a valuable chemical probe for studying the role of GSPT1/2 in vitro and in vivo.

物理化学性质&存储条件

分子量	497.401
分子式	C20H14F3N3O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide

参考文献

1. Gisele Nishiguchi, et al. J Med Chem. 2021 Jun 10;64(11):7296-7311.

SJ6986 (SJ 6986, SJ-6986)

生物&药学活性

物理化学性质&存储条件

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SJ6986 (SJ 6986, SJ-6986)

生物&药学活性

物理化学性质&存储条件

参考文献

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