欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-抗体药物偶连体和PROTACs-PROTAC-dIRF4-2
dIRF4-2

Chemical Structure : dIRF4-2

CAS No.: 3114433-45-0

加入收藏

dIRF4-2 (IRF4 PROTAC degrader)

货号: PC-27186Not For Human Use, Lab Use Only.

dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h).

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h).
    dIRF4-2 shows rapid IRF4 depletion at 2 hours and as low as 1 µM concentrations in both MM1.S and OPM2 cell lines.
    dIRF4-2 shows no neosubstrate degradation, dIRF4-2 can redirect CRBN to the nucleus to initiation degradation of IRF4, as measured by significant increases in Pearson correlation between IRF4 and CRBN.
    dIRF4-2 phenocopies the effect of IRF4 loss, and is cytotoxic across IRF4-dependent MM cell models (IC50=700-800 nM).

    物理化学性质&存储条件

    分子量 786.89
    分子式 C43H46N8O7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1S)-1-(3-(1-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propyl)-1H-pyrazol-4-yl)phenyl)-2-(methylamino)-2-oxoethyl)-1-(4-methoxyphenyl)cyclopropane-1-carboxamide

    参考文献

    1. Agius MP, et al. Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma. Nat Chem Biol. 2026 May 28.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: