SMD-6346 | SMARCA2 PROTAC | Probechem Biochemicals

Chemical Structure : SMD-6346

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SMD-6346 (SMD6346)

货号: PC-27120Not For Human Use, Lab Use Only.

SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%).

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100 mg		Get quote

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生物&药学活性

SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%).
SMD-6346 potently and effectively inhibits cell growth in SMARCA4-deficient cancer cell lines and displays minimal cell growth inhibition activity in SMARCA2/4 wild-type cancer cell lines.
SMD-6346 induces robust SMARCA2 depletion in tumor tissues in mice and significantly inhibits tumor growth in the H838 SMARCA4-deficient xenograft model in mice.

物理化学性质&存储条件

分子量	810.38
分子式	C46H50ClF2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(3-((4-(4'-chloro-5'-oxo-5'H-spiro[cyclohexane-1,7'-indolo[1,2-a]quinazolin]-10'-yl)piperidin-1-yl)methyl)-1-oxa-9-azaspiro[5.5]undecan-9-yl)-2,6-difluorophenyl)piperidine-2,6-dione

参考文献

1. Leng L, et al. J Med Chem. 2026 Jun 23. doi: 10.1021/acs.jmedchem.6c01093.

SMD-6346 (SMD6346)

生物&药学活性

物理化学性质&存储条件

参考文献

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SMD-6346 (SMD6346)

生物&药学活性

物理化学性质&存储条件

参考文献

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