JNJ-1013 | IRAK1 PROTAC | Probechem Biochemicals

Chemical Structure : JNJ-1013

CAS No.: 2597343-08-1

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JNJ-1013 (JNJ1013)

货号: PC-27068Not For Human Use, Lab Use Only.

JNJ-1013 is a highly potent, selective interleukin-1 receptor-associated kinase 1 (IRAK1) PROTAC degrader with DC50 of 3 nM in HBL-1 cells, Dmax=96%.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

JNJ-1013 is a highly potent, selective interleukin-1 receptor-associated kinase 1 (IRAK1) PROTAC degrader with DC50 of 3 nM in HBL-1 cells, Dmax=96%.
JNJ-1013inhibits cell proliferation of HBL-1 cells with IC50 of 0.06 uM.
JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP.
JNJ-1013 potently inhibited IRAK1 downstream signaling pathways and demonstrated strong anti-proliferative effects in ABC DLBCL cells with MyD88 mutation.

物理化学性质&存储条件

分子量	878.06
分子式	C46H55N9O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(2-(((S)-1-((2S,4R)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)piperidin-1-yl)-2-methoxyphenyl)-6-(1H-pyrazol-5-yl)picolinamide

参考文献

1. Liqiang Fu, et al. J Med Chem. 2021 Aug 12;64(15):10878-10889.

JNJ-1013 (JNJ1013)

生物&药学活性

物理化学性质&存储条件

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JNJ-1013 (JNJ1013)

生物&药学活性

物理化学性质&存储条件

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