| Cat. No. |
Product Name |
Information |
| PC-27988 |
RP04340
KRAS PROTAC
|
RP04340 is a potent and orally bioavailable pan-KRAS PROTAC degrader, potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates. |
| PC-27888 |
ASM130
NUDT5 PROTAC
|
ASM130 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 7 nM in HEK293 cells (20h incubation), Dmax=73%. |
| PC-27887 |
ASM127
NUDT5 PROTAC
|
ASM127 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 12 nM in HEK293 cells (20h incubation), Dmax=71%. |
| PC-27785 |
Z5000181945
RNF39 degrader
|
Z5000181945 is a small molecule glue degrader of E3 ubiquitin ligase RNF39, enhances the RNF39-CRBN interaction, induces degradation of the RNF39 RING finger domain, which is rescued by the NEDD8-activating enzyme (NAE) inhibitor MLN4924. |
| PC-27784 |
FIZ1 degrader 1
FIZ1 degrader
|
FIZ1 degrader 1 is a small molecule degrader zinc-finger protein FIZ1 (Flt3-interacting zinc finger protein 1). |
| PC-27736 |
DK-5070
GPX4 degrader
|
DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h). |
| PC-27715 |
dTAGV-1
FKBP12F36V PROTAC
|
dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins. |
| PC-27629 |
DOT1L808
DOT1L PROTAC
|
DOT1L808 is potent and highly selective DOT1L PROTAC degrader with DC50 of 5 nM. |
| PC-27577 |
PinA1
CK1⍺ degrader
|
PinA1 is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27547 |
dACSL4
ACSL4 degrader
|
dACSL4 is a potent, selective PROTAC degrader targeting ACSL4 (DC50=103 nM, SH-SY5Y cells) by conjugating troglitazone to the CRBN-binding ligand pomalidomide, concurrently degrades ACSL4 and activates PPARγ signaling. |
| PC-27503 |
Sovutrecdeg
TRK degrader
|
Sovutrecdeg (CG001419) is a first-in-class, selective, potent oral degrader of pan-tropomyosin receptor kinase (TRK), selectively degrades both mutant and wild-type TRK proteins. |
| PC-27493 |
Reziciclideg
CDK4/6 degrader
|
Reziciclideg (BTX-9341) is a potent, seletive, blood-brain barrier permeable cereblon-mediated bifunctional degrader of CDK4 and CDK6 with Kd of 31 nM (CDK6). |
