dACSL4

Chemical Structure : dACSL4

加入收藏

货号: PC-27547Not For Human Use, Lab Use Only.

dACSL4 is a potent, selective PROTAC degrader targeting ACSL4 (DC50=103 nM, SH-SY5Y cells) by conjugating troglitazone to the CRBN-binding ligand pomalidomide, concurrently degrades ACSL4 and activates PPARγ signaling.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

dACSL4 is a potent, selective PROTAC degrader targeting ACSL4 (DC50=103 nM, SH-SY5Y cells) by conjugating troglitazone to the CRBN-binding ligand pomalidomide, concurrently degrades ACSL4 and activates PPARγ signaling.
dACSL4 induced ACSL4 degradation through the UPS, MG-132 prohibits dACSL4-mediated ACSL4 degradation.
dACSL4 degrades ACSL4 through CRBN-mediated ubiquitination and subsequent proteasomal degradation.
dACSL4 demonstrates robust PPARγ activation, approximating 90% of the efficiency of the parent ligand, troglitazone (TRO), with an EC50 value of approximately 760 nM.
dACSL4 shows significant reduction for other ACSL isoforms, such as ACSL1, ACSL3, and ACSL5.
dACSL4 enables efficient ACSL4 degradation while preventing productive ternary complex formation with PPARγ, thereby preserving its functional activation.
dACSL4 inhibits neuronal ferroptosis, effectively inhibits both lipid peroxide (LPO) elevation and cell death in SH-SY5Y cells exposed to 100 μM of 6-OHDA.
dACSL4 exhibits dose-dependent protection against RSL3-induced neurotoxicity.
DACSL4 suppresses ferroptosis via PUFA remodeling and PPARγ-GPX4 axis activation.
Intranasal delivery of dACSL4 using biodegradable lipid nanoparticles (BAmP-TK12) enabled brain-preferred ACSL4 degradation and PPARγ activation, reducing lipid peroxidation and preserving dopaminergic neurons in a Parkinson’s disease model, ultimately improving motor function.

物理化学性质&存储条件

分子量	872.99
分子式	C45H52N4O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-((6-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione

参考文献

1. Ma T, et al. Cell Chem Biol. 2026 Jul 21:S2451-9456(26)00234-5.

dACSL4

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

dACSL4

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.