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首页-抗体药物偶连体和PROTACs-PROTAC-DOT1L808
DOT1L808

Chemical Structure : DOT1L808

CAS No.: 3124614-35-0

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DOT1L808

货号: PC-27629Not For Human Use, Lab Use Only.

DOT1L808 is potent and highly selective DOT1L PROTAC degrader with DC50 of 5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DOT1L808 is potent and highly selective DOT1L PROTAC degrader with DC50 of 5 nM.
DOT1L808 exhibits cell viability inhibition, which is highly dependent on the MLL-r status of leukemia cell lines, and retains activity against menin inhibitor-resistant cells.
DOT1L808 achieves complete tumor regression in an orthotopic leukemia model without overt toxicity.

物理化学性质&存储条件

分子量 1301.90
分子式 C61H72ClF3N14O9S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Quan S, et al. J Med Chem. 2026 Feb 26;69(4):4439-4468.

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