MJP6412 | p300/CBP PROTAC | Probechem Biochemicals

Chemical Structure : MJP6412

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MJP6412 (MJP-6412)

货号: PC-28354Not For Human Use, Lab Use Only.

MJP6412 is a potent, selective p300/CBP PROTAC degrader with DC50 of 1.6-3.4 nM for p300 and 1.2-3.7 nM for CBP in 22Rv1 cells, inhibits cell growth of 22Rv1 cells with IC50 of 37.6 nM.

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生物&药学活性

MJP6412 is a potent, selective p300/CBP PROTAC degrader with DC50 of 1.6-3.4 nM for p300 and 1.2-3.7 nM for CBP in 22Rv1 cells, inhibits cell growth of 22Rv1 cells with IC50 of 37.6 nM.
MJP6412 inhibits cell growth of human prostate cancer cell lines and enzalutamide-resistant cells at nanomolar concentrations.
MJP6412 demonstrates significant inhibition of tumor growth in a VCaP xenograft model.

物理化学性质&存储条件

分子量	1009.06
分子式	C55H54F2N8O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((1S,4r)-4-(2-((S)-1-(3,4-difluorophenyl)-6-oxopiperidin-2-yl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-yl)cyclohexyl)oxy)-N-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)oxy)phenyl)acetamide

参考文献

1. Ma M, et al. J Med Chem. 2024 Sep 29. doi: 10.1021/acs.jmedchem.4c01100.

MJP6412 (MJP-6412)

生物&药学活性

物理化学性质&存储条件

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MJP6412 (MJP-6412)

生物&药学活性

物理化学性质&存储条件

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