RP04340 | KRAS PROTAC | Probechem Biochemicals

Chemical Structure : RP04340

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RP04340 (RP-04340)

货号: PC-27988Not For Human Use, Lab Use Only.

RP04340 is a potent and orally bioavailable pan-KRAS PROTAC degrader, potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates.

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生物&药学活性

RP04340 is a potent and orally bioavailable pan-KRAS PROTAC degrader, potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates.

物理化学性质&存储条件

分子量	1049.16
分子式	C56H61F5N10O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-(1-(7-(((R)-1-(((7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-4-((S)-1-oxa-6-azaspiro[3.5]nonan-6-yl)pyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)-2,2-difluorocyclopropyl)methyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)-5-fluoro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione

参考文献

1. Xiang Ji, et al. J Med Chem. 2026 Aug 27;69(16):19982-19998.

RP04340 (RP-04340)

生物&药学活性

物理化学性质&存储条件

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RP04340 (RP-04340)

生物&药学活性

物理化学性质&存储条件

参考文献

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