DK-5070 | GPX4 degrader | Probechem Biochemicals

Chemical Structure : DK-5070

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DK-5070 (DK5070)

货号: PC-27736Not For Human Use, Lab Use Only.

DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h).

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生物&药学活性

DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h).
DK-5070 induced pronounced GPX4 degradation following 24 h treatment at 50 nM.
DK-5070 (20 nM) achieved greater GPX4 degradation than dGPX4 at 200 nM.
DK-5070 exhibits antiproliferative activity against with IC50 of 47 nM in HT1080 cells.
DK-5070 induces rapid and durable GPX4 degradation via the ubiquitin-proteasome system.
DK-5070 covalently recruits UHRF1 to mediate the degradation of GPX4 via the proteasome pathway, enhances the GPX4-UHRF1 interaction with Kd of 1.02 uM.
DK-5070 suppresses cell proliferation primarily through GPX4 degradation-induced ferroptosis.
DK-5070 (10-30 mg/kg) significantly suppressed tumor growth in a dose-dependent manner in HT1080 xenograft mouse models.

物理化学性质&存储条件

分子量	532.44
分子式	C24H23Cl2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-azidoethoxy)-3-chlorophenyl)-2-chloro-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide

参考文献

1. Lin Z, et al. Adv Sci (Weinh). 2026 Aug 19:e77201.

DK-5070 (DK5070)

生物&药学活性

物理化学性质&存储条件

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DK-5070 (DK5070)

生物&药学活性

物理化学性质&存储条件

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