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首页-抗体药物偶连体和PROTACs-PROTAC-ASM130
ASM130

Chemical Structure : ASM130

CAS No.: 3044792-12-0

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ASM130 (ASM-130)

货号: PC-27888Not For Human Use, Lab Use Only.

ASM130 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 7 nM in HEK293 cells (20h incubation), Dmax=73%.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ASM130 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 7 nM in HEK293 cells (20h incubation), Dmax=73%.

物理化学性质&存储条件

分子量 994.84
分子式 C44H49Cl2N11O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-8-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Marques AMC, et al. Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response. Nat Commun. 2026 Jun 30;17(1):8192.

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