ASM127 | NUDT5 PROTAC | Probechem Biochemicals

Chemical Structure : ASM127

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ASM127 (ASM-127)

货号: PC-27887Not For Human Use, Lab Use Only.

ASM127 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 12 nM in HEK293 cells (20h incubation), Dmax=71%.

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100 mg		Get quote

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生物&药学活性

ASM127 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 12 nM in HEK293 cells (20h incubation), Dmax=71%.

物理化学性质&存储条件

分子量	950.79
分子式	C42H45Cl2N11O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-8-(4-(3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoyl)piperazin-1-yl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Marques AMC, et al. Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response. Nat Commun. 2026 Jun 30;17(1):8192.

ASM127 (ASM-127)

生物&药学活性

物理化学性质&存储条件

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ASM127 (ASM-127)

生物&药学活性

物理化学性质&存储条件

参考文献

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