Z5000181945

Chemical Structure : Z5000181945

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货号: PC-27785Not For Human Use, Lab Use Only.

Z5000181945 is a small molecule glue degrader of E3 ubiquitin ligase RNF39, enhances the RNF39-CRBN interaction, induces degradation of the RNF39 RING finger domain, which is rescued by the NEDD8-activating enzyme (NAE) inhibitor MLN4924.

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生物&药学活性

Z5000181945 is a small molecule glue degrader of E3 ubiquitin ligase RNF39, enhances the RNF39-CRBN interaction, induces degradation of the RNF39 RING finger domain, which is rescued by the NEDD8-activating enzyme (NAE) inhibitor MLN4924.

物理化学性质&存储条件

分子量	467.54
分子式	C23H25N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-3-((5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-2-yl)methyl)urea

参考文献

1. Galli P, et al. Nat Biotechnol. 2026 Aug 13. doi: 10.1038/s41587-026-03237-7.

Z5000181945

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Z5000181945

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