Zilucoplan | Complement C5 inhibitor | Probechem Biochemicals

Chemical Structure : Zilucoplan

CAS No.: 1841136-73-9

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Zilucoplan (RA101495, RA3193)

货号: PC-24490Not For Human Use, Lab Use Only.

规格	价格	库存
500 ug	￥2480	In stock
1 mg	￥3980	In stock
2 mg	￥5980	In stock
5 mg		Get quote
10 mg		Get quote

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生物&药学活性

Zilucoplan (RA101495) is a potent, selective macrocyclic peptide inhibitor of complement C5, binds to C5 with high affinity and specificity, prevents the cleavage of C5 into complement components C5a and C5b.
Zilucoplan (RA101495) binds to the domain of C5 that corresponds to C5b and thereby blocks binding of C5b to complement component C6.
Zilucoplan (RA101495) prevents activation of the terminal complement pathway and prevents assembly of the terminal complement complex (previously known as membrane attack complex [C5b-9]), a large hydrophilic pore that can damage and destroy the postsynaptic membrane, disrupt ionic channel conductance, and impair neuromuscular transmission.
Zilucoplan (RA101495) shows profound effects on inhibiting acute lung injury post COVID-19, and can promote lung repair mechanisms, shows potential therapeutic in generalized myasthenia gravis.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Howard JF Jr, et al. JAMA Neurol. 2020 May 1;77(5):582-592.

Zilucoplan (RA101495, RA3193)

生物&药学活性

物理化学性质&存储条件

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Zilucoplan (RA101495, RA3193)

生物&药学活性

物理化学性质&存储条件

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