IHMT-MST1-58

Chemical Structure : IHMT-MST1-58

CAS No.: 2414484-25-4

加入收藏

货号: PC-49294Not For Human Use, Lab Use Only.

IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
IHMT-MST1-58 inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro.
IHMT-MST1-58 displayed acceptable pharmacokinetic properties in different species.
Both monotherapy of IHMT-MST1-58 and in combination with metformin led to the decline of fasting blood glucose and showed protective effect of β cells in the STZ-induced T1D/T2D mouse models.
IHMT-MST1-58 and metformin decreased the hemoglobin A1c level.

物理化学性质&存储条件

分子量	438.506
分子式	C21H22N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5,8-dimethyl-6-oxo-7-(o-tolyl)-5,6,7,8-tetrahydropteridin-2-yl)amino)benzenesulfonamide

参考文献

1. Wu Y, et al. J Med Chem. 2022 Aug 29. doi: 10.1021/acs.jmedchem.2c00926.

IHMT-MST1-58

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IHMT-MST1-58

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.