AP503 (AP-970/43482503) | GPR133 agonist | Probechem Biochemicals

Chemical Structure : AP503

CAS No.: 767299-99-0

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AP503 (AP-503, AP-970/43482503)

货号: PC-24037Not For Human Use, Lab Use Only.

AP503 (AP-970/43482503) is a potent, specific small molecule agonist of androgen membrane receptor GPR133 (ADGRD1) with EC50 of 1.21 nM.

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2 mg	￥2180	In stock
5 mg	￥3580	In stock
10 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

AP503 (AP-970/43482503) is a potent, specific small molecule agonist of androgen membrane receptor GPR133 (ADGRD1) with EC50 of 1.21 nM.

AP503 activates the Gs but not the G12 or Gi pathway of GPR133.

AP503 shows no detectable activity for AR or other aGPCR members.

AP503 enhances muscle strength without eliciting androgenic adverse effects, significantly promotes the tetanic contraction forces of isolated EDLs through PKA-mediated signaling.

GPR133 represents an androgen membrane receptor that contributes to normal androgen physiology and has important therapeutic potentials.

物理化学性质&存储条件

分子量	425.53
分子式	C24H31N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-(2-(2,4-dimethylphenoxy)acetamido)-4-(4-ethylpiperazin-1-yl)benzoate

参考文献

1. Yang Z, et al. Cell. 2025 Jan 23:S0092-8674(25)00035-2.

AP503 (AP-503, AP-970/43482503)

生物&药学活性

物理化学性质&存储条件

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AP503 (AP-503, AP-970/43482503)

生物&药学活性

物理化学性质&存储条件

参考文献

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