AZD3514 | AR inhibitor | Probechem Biochemicals

Chemical Structure : AZD3514

CAS No.: 1240299-33-5

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AZD3514 (AZD-3514)

货号: PC-25059Not For Human Use, Lab Use Only.

AZD3514 is an orally bioavailable small-molecule androgen receptor downregulator with pIC50 of 5.75, inhibits androgen-dependent and -independent AR signaling.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

AZD3514 is an orally bioavailable small-molecule androgen receptor downregulator with pIC50 of 5.75, inhibits androgen-dependent and -independent AR signaling.
AZD3514 modulates AR signaling through two distinct mechanisms, an inhibition of ligand-driven nuclear translocation of AR and a downregulation of receptor levels, both of which were observed in vitro and in vivo.
AZD3514 inhibited testosterone-driven seminal vesicle development in juvenile male rats and the growth of androgen-dependent Dunning R3327H prostate tumors in adult rats.
AZD3514 showed antitumor activity in the HID28 mouse model of CRPC in vivo.

物理化学性质&存储条件

分子量	519.57
分子式	C25H32F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethan-1-one

参考文献

1. Omlin A, et al. Invest New Drugs. 2015 Jun;33(3):679-90.

2. Loddick SA, et al. Mol Cancer Ther. 2013 Sep;12(9):1715-27.

3. Bradbury RH, et al. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8.

AZD3514 (AZD-3514)

生物&药学活性

物理化学性质&存储条件

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AZD3514 (AZD-3514)

生物&药学活性

物理化学性质&存储条件

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