| Cat. No. |
Product Name |
Information |
| PC-60518 |
CC-220
E3 ubiquitin ligase modulator
|
Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM. |
| PC-45731 |
PRT4165
PRC1 inhibitor
|
PRT4165 (NSC 600157) is a potent inhibitor of PRC1-mediated H2A ubiquitylation, inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8. |
| PC-46931 |
Suramin sodium salt
Cullin-RING E3 ubiquitin ligase inhibitor
|
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34. |
| PC-42099 |
SZL P1-41
Skp2 inhibitor
|
SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
| PC-24781 |
NEDD4 inhibitor 32
NEDD4 inhibitor
|
NEDD4 inhibitor 32 is a selective, covalent inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination. |
| PC-24708 |
Skp2 inhibitor E35
Skp2 inhibitor
|
Skp2 inhibitor E35 (HK-E35) is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 4.8 uM against Skp2-Cks1 binding. |
| PC-24707 |
Skp2 inhibitor 10h
Skp2 inhibitor
|
Skp2 inhibitor 10h is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 0.38 uM against Skp2-Cks1 binding. |
| PC-24706 |
ZK-14i
Skp2 inhibitor
|
ZK-14i (Skp2 inhibitor 14i) is a potent inhibitor of S-phase kinase-associated protein 2 (Skp2) with IC50 of 2.8 uM against the Skp2-Cks1 interaction. |
| PC-24524 |
GS143
E3 ligase β-TrCP inhibitor
|
GS143 is a specific small molecule inhibitor of E3 ligase β-TrCP, exhibits potent latency reversing agent (LRA) activity, also is a NF-kappaB signaling inhibitor, inhibits IκBα ubiquitylation (IC50=5.2 uM). |
| PC-24059 |
Lanatoside C
DENV inhibitor, FOXP3 inhibitor
|
Lanatoside C is a cardiac glycoside, has an IC50 of 0.19 μM for dengue virus (DENV) infection in HuH-7 cells, also potently inhibits FOXP3 activity by causing degradation of RUNX1, directly binds the E3 ligase STUB1 (ITC, Ka=13 uM). |
| PC-23887 |
Hakin-1
Hakai inhibitor
|
Hakin-1 (Hakai inhibitor-1) is a specific small molecule inhibitor of the E3 ubiquitin-ligase Hakai, reduces Hakai-mediated total ubiquitination and Hakai-mediated ubiquitination of E-cadherin. |
| PC-23661 |
Y043-4427
DTX2 inhibitor
|
Y043-4427 (mDTX2i, C22H24N4O2) is a potent small molecule inhibitor of Deltex E3 ubiquitin ligase 2 (DTX2) with IC50 of 30.83 uM in Hepa1-6 cells. |
