| Cat. No. |
Product Name |
Information |
| PC-61253 |
DT204
SCFSkp2 inhibitor
|
DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis. |
| PC-70324 |
Heclin
HECT ligase inhibitor
|
Heclin is a small molecule inhibitor of HECT-type E3 ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively. |
| PC-61192 |
SCF-I2
SCFCdc4 inhibitor
|
SCF-I2 is an allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assays. |
| PC-60879 |
BC-1215
Fbxo3 inhibitor
|
BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL. |
| PC-60547 |
BC-1382
HECTD2 inhibitor
|
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM. |
| PC-60518 |
CC-220
E3 ubiquitin ligase modulator
|
Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM. |
| PC-45731 |
PRT4165
PRC1 inhibitor
|
PRT4165 (NSC 600157) is a potent inhibitor of PRC1-mediated H2A ubiquitylation, inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8. |
| PC-46931 |
Suramin sodium salt
Cullin-RING E3 ubiquitin ligase inhibitor
|
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34. |
| PC-42099 |
SZL P1-41
Skp2 inhibitor
|
SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
| PC-25478 |
Skp2-Cks1 inhibitor E35
Skp2 inhibitor
|
Skp2-Cks1 inhibitor E35 is a potent small molecule inhibitor of S-phase kinase-associated protein 2 (Skp2), inhbits Skp2-Cks1 protein-protein interaction (PPI) with IC50 of 4.86 uM. |
| PC-25377 |
A5-MMC17
FBW7 modulator
|
A5-MMC17 is a specific, small molecule allosteric modulator of FBW7 E3 ligase with MST Kd of 45 uM, targets FBW7-pocket G, induces proteasome- and Cullin-RING-dependent c-MYC and c-JUN degradation in cells. |
| PC-25147 |
OICR-41103
DCAF1 ligand
|
OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein. |
