BI8626 (BI-8626) | HUWE1 inhibitor | Probechem Biochemicals

Chemical Structure : BI8626

CAS No.: 1875036-75-1

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BI8626 (BI-8626, BI 8626)

货号: PC-63515Not For Human Use, Lab Use Only.

BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM).
BI8626 suppresses colony formation of Ls174T cells with IC50 of 0.7 uM.
BI8626 inhibits MYC-dependent transactivation in colorectal cancer cells, but not in stem and normal colon epithelial cells.
BI8626 stabilizes MYC-associated protein MIZ1.

物理化学性质&存储条件

分子量	440.555
分子式	C25H28N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine

参考文献

1. Peter S, et al. EMBO Mol Med. 2014 Dec;6(12):1525-41.

BI8626 (BI-8626, BI 8626)

生物&药学活性

物理化学性质&存储条件

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BI8626 (BI-8626, BI 8626)

生物&药学活性

物理化学性质&存储条件

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