Nimbolide

Chemical Structure : Nimbolide

CAS No.: 25990-37-8

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货号: PC-21374Not For Human Use, Lab Use Only.

Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping.
Nimbolide treatment is synthetically lethal in BRCA-deficient tumor cells.
Nimbolide is also able to kill BRCA-deficient tumor cells with intrinsic and acquired resistance to conventional PARPi.
Nimbolide has significant bactericidal activity against H. pylori, killing both free living bacterial cells as well as cells within a biofilm.
Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling.

物理化学性质&存储条件

分子量	466.53
分子式	C27H30O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate

参考文献

1. Li P, et al. Sci Adv. 2023 Oct 27;9(43):eadg7752.

2. Mehmetoglu-Gurbuz T, et al. Antioxidants (Basel). 2023 Sep 22;12(10):1791.

3. Wylie MR, et al. J Ethnopharmacol. 2022 Mar 1;285:114828.

Nimbolide

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