T0467 | PINK1-Parkin activator | Probechem Biochemicals

Chemical Structure : T0467

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T0467 (T 0467)

货号: PC-20550Not For Human Use, Lab Use Only.

T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.

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生物&药学活性

T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
T0467 stimulates the mitochondrial translocation of Parkin in a PINK1-dependent manner.
T0467 reduces unfolded mitochondrial protein levels, presumably through enhanced PINK1-Parkin signaling.
T0467 mitigates the locomotion defect, reduced ATP production, and disturbed mitochondrial Ca2+ response in the muscles along with the mitochondrial aggregation in dopaminergic neurons through reduced PINK1 activity in Drosophila.

物理化学性质&存储条件

分子量	441.50
分子式	C24H26F3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3,5-difluorophenethyl)-4-(2-fluoro-5-((2-methylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-amine

参考文献

1. Shiba-Fukushima K, et al. iScience. 2020 May 22;23(5):101048.

T0467 (T 0467)

生物&药学活性

物理化学性质&存储条件

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T0467 (T 0467)

生物&药学活性

物理化学性质&存储条件

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